HitPredict

Interactor 1: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Interactor 2: MYLK2 (Q9H1R3)
Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18)
Gene: MYLK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	21182203, 25604459
Identification Methods	affinity chromatography technology, cosedimentation through density gradient, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 530 Hs			1 596
+	Hs
		370414 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		MYLK2_HUMAN (1-596): 0: 528: 100.00
+	Hs
		1039133 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		KCC2D_HUMAN (280-596): 5.43e-133: 399: 30.53
+	Hs
		369067 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		AKT2_HUMAN (172-594): 1.37e-136: 408: 21.09
+	Hs
		369066 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		AKT1_HUMAN (172-588): 3.1e-135: 404: 21.43
+	Hs
		377129 GCR_HUMAN (3-495): 1.12e-103: 330: 22.64		AKT1_HUMAN (172-588): 3.1e-135: 404: 21.43
+	Hs
		377307 GCR_HUMAN (3-495): 1.12e-103: 330: 22.64		KCC2D_HUMAN (280-596): 5.43e-133: 399: 30.53
+	Hs
		487911 RARA_HUMAN (52-505): 3.54e-105: 324: 23.74		AKT1_HUMAN (172-588): 3.1e-135: 404: 21.43
+	Hs
		622765 COT2_HUMAN (77-502): 2.24e-102: 316: 23.90		AKT2_HUMAN (172-594): 1.37e-136: 408: 21.09
+	Hs
		611379 NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30		AKT1_HUMAN (172-588): 3.1e-135: 404: 21.43
+	Hs
		622764 COT2_HUMAN (77-502): 2.24e-102: 316: 23.90		AKT1_HUMAN (172-588): 3.1e-135: 404: 21.43
+	Hs
		200130 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		DAPK3_HUMAN (271-566): 4.44e-67: 227: 40.06
+	Hs
		1264774 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		TITIN_HUMAN (289-591): 2.8e-56: 207: 35.97
+	Hs
		370105 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		TITIN_HUMAN (289-591): 2.8e-56: 207: 35.97
+	Hs
		377204 GCR_HUMAN (3-495): 1.12e-103: 330: 22.64		DAPK1_HUMAN (271-540): 5.04e-64: 230: 42.09
+	Hs
		487170 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		AKT1_HUMAN (172-588): 3.1e-135: 404: 21.43
+	Hs
		377539 GCR_HUMAN (3-495): 1.12e-103: 330: 22.64		TITIN_HUMAN (289-591): 2.8e-56: 207: 35.97