Protein: PRKN
E3 ubiquitin-protein ligase parkin (EC 2.3.2.31)

Gene: PRKN, park
Organism: Drosophila melanogaster
Interactions: 57
UniProt ID: Q7KTX7

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0000266 - mitochondrial fission
GO:0000423 - mitophagy
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1269561

PRKN
E3 ubiquitin-protein ligase parkin

2

17

Small-scale

0.768

High

1269575

Q9VEJ4
Ubiquitin-conjugating enzyme E2 J2

2

20

High-throughput

0.767

High

1070722

PINK1
Serine/threonine-protein kinase Pink1, mitochondrial

2

16

Small-scale

0.754

High

1269563

MARF
Transmembrane GTPase Marf

3

5

Small-scale

0.657

High

1269584

Q9VUV7
E3 ubiquitin-protein ligase NRDP1

1

20

Small-scale

0.621

High

304558

ARI2
Potential E3 ubiquitin-protein ligase ariadne-2

1

19

Small-scale

0.618

High

762716

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.618

High

1269564

Q86NK9
Protein deacetylase HDAC6

1

10

Small-scale

0.618

High

1269572

ARI1
E3 ubiquitin-protein ligase ariadne-1

1

15

Small-scale

0.618

High

1261772

Q7JRF1
RE48509p

2

1

High-throughput

0.594

High

1269574

ZFPL1
Zinc finger protein-like 1 homolog

2

2

High-throughput

0.594

High

723791

DLG1
Disks large 1 tumor suppressor protein

1

11

High-throughput

0.587

High

1269576

Q9VIL1
Transmembrane protein 230

2

0

High-throughput

0.569

High

1269579

Q9VPD4
Vesicle transport protein

2

0

High-throughput

0.569

High

1269571

Q8SYY7
RE27547p

2

6

High-throughput

0.542

High

1269581

Q9VQT8
Immune induced molecule 33, isoform A

2

6

High-throughput

0.542

High

1269585

Q9VVX6
BET1 homolog

2

1

High-throughput

0.542

High

1269562

Q7KUX3
Septin

1

12

Small-scale

0.512

High

1267201

Q7KJA9
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

10

High-throughput

0.508

High

1269568

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

1

High-throughput

0.494

High

654029

DSX
Protein doublesex

1

0

High-throughput

0.486

High

56551

CLU
Protein clueless

1

10

Small-scale

0.479

High

874929

IF4E
Eukaryotic translation initiation factor 4E1

1

3

Small-scale

0.479

High

875576

PELO
Protein pelota

1

3

Small-scale

0.479

High

1269565

MIRO
Mitochondrial Rho GTPase

1

16

Small-scale

0.479

High

1269582

PARIS
Zinc finger protein Paris

1

11

Small-scale

0.479

High

1269583

ABCE1
Protein Pixie

1

5

Small-scale

0.479

High

57399

MED9
Mediator of RNA polymerase II transcription subunit 9

1

1

High-throughput

0.464

High

119833

HAKAI
E3 ubiquitin-protein ligase Hakai

1

2

High-throughput

0.457

High

1269567

Q8MLR2
Entomoglyceroporin 4, isoform C

1

2

High-throughput

0.451

High

1269578

Q9VMN4
Uncharacterized protein, isoform B

1

1

High-throughput

0.451

High

1269580

Q9VPN0
GH04039p

1

1

High-throughput

0.451

High

1269587

Q9W4B3
Visual system homeobox 2

1

4

High-throughput

0.451

High

68412

A8DYS6
IP17118p

1

1

High-throughput

0.439

High

81994

B6IDP6
FI06437p

1

1

High-throughput

0.439

High

92096

D1Z394
Entomoglyceroporin 4, isoform E

1

2

High-throughput

0.439

High

1269591

X2JDS9
Visual system homeobox 2

1

4

High-throughput

0.439

High

52200

A1Z6Q0
Klaroid, isoform D

1

1

Small-scale

0.437

High

828123

PNUT
Protein peanut

1

12

Small-scale

0.437

High

837961

SEPT1
Septin-1

1

12

Small-scale

0.437

High

54794

A1Z8Z3
Cuticular protein 49Ag

2

0

High-throughput

0.310

High

356966

U729
UPF0729 protein CG18508

2

0

High-throughput

0.310

High

1069873

Q0E985
RH74701p

2

0

High-throughput

0.310

High

1263970

Q7K087
GEO08225p1

2

0

High-throughput

0.310

High

1265404

Q7K2P1
Cuticular protein 50Cb

2

0

High-throughput

0.310

High

1269566

Q8IQ76
GEO12894p1

2

0

High-throughput

0.310

High

1269569

Q8SY76
RH45738p

2

0

High-throughput

0.310

High

1269570

Q8SYA4
Bomanin short 4

2

0

High-throughput

0.310

High

1269573

AQP
Aquaporin

2

0

High-throughput

0.310

High

1269577

Q9VLL8
Peritrophin-15a

2

0

High-throughput

0.310

High

1269586

TM14
Transmembrane protein 14 homolog

2

0

High-throughput

0.310

High

1269588

Q9W4B6
RE01432p

2

0

High-throughput

0.310

High

1269589

Q9W4S5
IP07779p

2

0

High-throughput

0.310

High

56078

A1Z9T6
Uncharacterized protein

1

0

High-throughput

0.265

Low

1262548

Q7JWN2
RE25177p

1

0

High-throughput

0.265

Low

1269590

Q9XTN4
Brinker

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025