HitPredict

Interactor 1: TFG (Q92734)
Protein TFG (TRK-fused gene protein)
Gene: TFG

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 1620
+	Hs
		302332 SC31A_HUMAN (98-394): 1.59e-27: 116: 13.29		ALK_HUMAN (1-1620): 0: 1883: 100.00
+	Hs
		169192 TFG_HUMAN (1-400): 4.64e-79: 250: 100.00		MUSK_HUMAN (983-1391): 2.02e-118: 396: 29.98
+	Hs
		508129 TFG_HUMAN (1-400): 4.64e-79: 250: 100.00		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		123859 SPT5H_HUMAN (105-292): 2.84e-09: 61.1: 9.62		LTK_HUMAN (606-1458): 6.35e-175: 550: 53.24
+	Hs
		302241 SC31A_HUMAN (98-394): 1.59e-27: 116: 13.29		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Mm
		724168 SHAN3_MOUSE (129-398): 4.33e-21: 97.7: 19.93		RET_MOUSE (843-1477): 2.28e-128: 431: 23.21
+	Hs
		203204 SYNJ1_HUMAN (131-397): 5.05e-30: 124: 15.81		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		169154 SC31A_HUMAN (98-394): 1.59e-27: 116: 13.29		MUSK_HUMAN (983-1391): 2.02e-118: 396: 29.98
+	Hs
		302247 SC31A_HUMAN (98-394): 1.59e-27: 116: 13.29		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		302242 SC31A_HUMAN (98-394): 1.59e-27: 116: 13.29		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Rn
		102464 G3V699_RAT (107-394): 7.35e-21: 96.9: 13.06		INSR_RAT (973-1484): 1.45e-112: 392: 32.38
+	Hs
		445876 SHAN3_HUMAN (126-398): 1.2e-16: 84.2: 18.18		ROS1_HUMAN (1039-1461): 3.68e-112: 397: 37.75
+	Hs
		385276 TFG_HUMAN (1-400): 4.64e-79: 250: 100.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		1081554 TFG_HUMAN (1-400): 4.64e-79: 250: 100.00		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Hs
		302238 SC31A_HUMAN (98-394): 1.59e-27: 116: 13.29		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		302291 SC31A_HUMAN (98-394): 1.59e-27: 116: 13.29		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Hs
		385629 OGFR_HUMAN (124-395): 2.69e-23: 103: 14.79		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		1081558 SHIP1_HUMAN (151-390): 5.03e-24: 106: 15.97		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Hs
		123828 SPT5H_HUMAN (105-292): 2.84e-09: 61.1: 9.62		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		384551 SC24C_HUMAN (97-340): 3.76e-09: 60.7: 14.69		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07