HitPredict

Interactor 1: HTRA1 (Q92743)
Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (L56) (Serine protease 11)
Gene: HTRA1

Interactor 2: HTRA1 (Q92743)
Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (L56) (Serine protease 11)
Gene: HTRA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.937

The method score is based on:

Property Details
Experiments 28642151, 21297635, 22578544, 29572155, 21622153
Identification Methods pull down, x-ray crystallography, molecular sieving, x ray scattering, protease assay
Interaction Type direct interaction, cleavage reaction, protein cleavage, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains IGFBP~Kazal_2, Kazal_2~Kazal_2, PDZ_6~PDZ_6, PDZ_6~Trypsin_2, Trypsin_2~Trypsin_2
Common GO terms GO:0001890 - placenta development
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005829 - cytosol
and 12 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 480
Hs

1 480
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ Ss
+ Ec
+ Ec
+ Ec
+ Sp
+ Hs
+ Dr
+ Hs
+ Hs
+ Sp
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024