HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: RERE (Q9P2R6)
Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein)
Gene: RERE

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	16481466, 21258344
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl
Common GO terms	GO:0000118 - histone deacetylase complex GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Hs			1 1566
+	Mm
		140291 HDAC1_MOUSE (1-443): 0: 645: 90.29		RERE_MOUSE (29-1566): 0: 624: 93.95
+	Hs
		1270415 HDAC2_HUMAN (1-488): 0: 707: 100.00		MTA3_HUMAN (104-705): 1.53e-156: 490: 22.17
+	Hs
		91458 HDAC1_HUMAN (1-443): 0: 642: 90.07		E7EQY4_HUMAN (104-635): 2.09e-164: 508: 23.51
+	Hs
		1031919 HDAC2_HUMAN (1-488): 0: 707: 100.00		MTA1_HUMAN (104-687): 6.13e-137: 442: 22.72
+	Mm
		936419 HDAC2_MOUSE (1-488): 0: 704: 99.39		MTA1_MOUSE (104-687): 1.3e-134: 435: 22.77
+	Mm
		936428 HDAC2_MOUSE (1-488): 0: 704: 99.39		MTA2_MOUSE (104-800): 7.16e-130: 421: 19.19
+	Hs
		296092 HDAC2_HUMAN (1-488): 0: 707: 100.00		MTA2_HUMAN (104-800): 1.6e-128: 417: 19.33
+	Dm
		1276548 HDAC1_DROME (5-472): 0: 653: 77.92		Q9VNF6_DROME (104-864): 1.28e-129: 427: 18.42
+	Mm
		140302 HDAC1_MOUSE (1-443): 0: 645: 90.29		MTA1_MOUSE (104-687): 1.3e-134: 435: 22.77
+	Mm
		140317 HDAC1_MOUSE (1-443): 0: 645: 90.29		MTA2_MOUSE (104-800): 7.16e-130: 421: 19.19
+	Dm
		81423 HDAC1_DROME (5-472): 0: 653: 77.92		B7Z0T5_DROME (109-864): 1.1e-122: 407: 18.50
+	Hs
		296017 HDAC1_HUMAN (1-443): 0: 642: 90.07		MTA2_HUMAN (104-800): 1.6e-128: 417: 19.33
+	Hs
		1270515 HDAC2_HUMAN (1-488): 0: 707: 100.00		RCOR1_HUMAN (284-584): 1.44e-53: 198: 16.56
+	Mm
		936418 HDAC2_MOUSE (1-488): 0: 704: 99.39		RCOR1_MOUSE (284-584): 3.55e-52: 193: 15.92
+	Hs
		1270488 HDAC2_HUMAN (1-488): 0: 707: 100.00		RCOR3_HUMAN (286-775): 8.29e-44: 169: 14.26
+	Mm
		140301 HDAC1_MOUSE (1-443): 0: 645: 90.29		RCOR1_MOUSE (284-584): 3.55e-52: 193: 15.92
+	Dm
		1123842 HDAC1_DROME (5-472): 0: 653: 77.92		RCOR_DROME (285-774): 3.7e-41: 163: 16.44
+	Dm
		1196991 HDAC1_DROME (5-472): 0: 653: 77.92		Q86BH2_DROME (479-1413): 1.51e-15: 84.9: 8.50
+	Dm
		1276528 HDAC1_DROME (5-472): 0: 653: 77.92		Q9NHX6_DROME (479-1413): 1.53e-15: 84.9: 9.14
+	Hs
		203227 HDAC1_HUMAN (1-443): 0: 642: 90.07		SYNJ1_HUMAN (1216-1550): 2.72e-09: 64.5: 11.11