Protein: MARK1
Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)

Gene: MARK1
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q9P0L2

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0000287 - magnesium ion binding
GO:0001764 - neuron migration
GO:0001786 - phosphatidylserine binding
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

376037

RASK
GTPase KRas

2

15

High-throughput

0.754

High

730302

1433B
14-3-3 protein beta/alpha

6

20

High-throughput

0.730

High

990809

1433Z
14-3-3 protein zeta/delta

6

20

Small-scale

0.730

High

530482

TAU
Microtubule-associated protein tau

6

9

Small-scale

0.727

High

1453880

CERT
Ceramide transfer protein

2

2

High-throughput

0.726

High

1209746

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

Small-scale

0.724

High

966957

1433G
14-3-3 protein gamma

5

20

High-throughput

0.712

High

909213

NEK4
Serine/threonine-protein kinase Nek4

1

16

High-throughput

0.691

High

920517

DAPK1
Death-associated protein kinase 1

1

13

High-throughput

0.691

High

1116079

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

12

High-throughput

0.691

High

1270541

MARK2
Serine/threonine-protein kinase MARK2

1

17

High-throughput

0.691

High

1049849

1433F
14-3-3 protein eta

4

20

High-throughput

0.691

High

691492

1433T
14-3-3 protein theta

4

20

High-throughput

0.678

High

972078

1433E
14-3-3 protein epsilon

3

20

Small-scale

0.650

High

1453869

MARK1
Serine/threonine-protein kinase MARK1

1

16

Small-scale

0.647

High

349268

LATS1
Serine/threonine-protein kinase LATS1

1

13

Small-scale

0.646

High

1122363

SCRIB
Protein scribble homolog

1

3

Small-scale

0.646

High

1154463

STK11
Serine/threonine-protein kinase STK11

1

19

Small-scale

0.646

High

710531

EPHA2
Ephrin type-A receptor 2

1

14

High-throughput

0.618

High

1004220

CXAR
Coxsackievirus and adenovirus receptor

1

2

High-throughput

0.618

High

1095471

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

18

Small-scale

0.618

High

1104887

SNTB2
Beta-2-syntrophin

1

7

High-throughput

0.618

High

1118460

SNTB1
Beta-1-syntrophin

1

8

High-throughput

0.618

High

1145143

RAB35
Ras-related protein Rab-35

1

5

High-throughput

0.618

High

1420971

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

6

High-throughput

0.618

High

1434099

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.618

High

1438207

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1453876

TPX2
Targeting protein for Xklp2

1

2

High-throughput

0.618

High

1453877

ALK
ALK tyrosine kinase receptor

1

17

High-throughput

0.618

High

862723

UTRN
Utrophin

2

13

High-throughput

0.611

High

1430808

CAD19
Cadherin-19

2

9

High-throughput

0.611

High

1453872

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

2

9

Small-scale

0.611

High

730927

1433S
14-3-3 protein sigma

2

20

High-throughput

0.601

High

352649

TCL1B
T-cell leukemia/lymphoma protein 1B

2

0

High-throughput

0.580

High

1081503

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

255254

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.575

High

1314064

YAF2
YY1-associated factor 2

2

2

High-throughput

0.553

High

1453875

PNMA2
Paraneoplastic antigen Ma2

2

8

High-throughput

0.549

High

783025

CXA5
Gap junction alpha-5 protein

1

5

High-throughput

0.541

High

1036697

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

4

High-throughput

0.536

High

1211519

CE85L
Centrosomal protein of 85 kDa-like

1

13

High-throughput

0.536

High

1453878

GPSM3
G-protein-signaling modulator 3

1

2

High-throughput

0.536

High

423354

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.515

High

431615

AP2A
Transcription factor AP-2-alpha

1

1

Small-scale

0.501

High

991947

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.493

High

1228731

C102B
Coiled-coil domain-containing protein 102B

1

15

High-throughput

0.481

High

159891

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

12

High-throughput

0.479

High

262443

DTNB
Dystrobrevin beta

1

10

High-throughput

0.479

High

373357

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.479

High

402461

FUCO
Tissue alpha-L-fucosidase

1

2

High-throughput

0.479

High

604248

CXA1
Gap junction alpha-1 protein

1

5

High-throughput

0.479

High

715818

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.479

High

786898

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

9

High-throughput

0.479

High

872828

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

905222

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

942933

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

1045852

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

1111734

STIM1
Stromal interaction molecule 1

1

5

High-throughput

0.479

High

1204845

DDX6L
Probable ATP-dependent RNA helicase DDX60-like

1

5

High-throughput

0.479

High

1216098

SPD2A
SH3 and PX domain-containing protein 2A

1

8

High-throughput

0.479

High

1233537

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1390307

TRI11
E3 ubiquitin-protein ligase TRIM11

1

1

Small-scale

0.479

High

1437071

AGO3
Protein argonaute-3

1

11

High-throughput

0.479

High

1439204

AGO4
Protein argonaute-4

1

11

High-throughput

0.479

High

1453870

HECW2
E3 ubiquitin-protein ligase HECW2

1

11

High-throughput

0.479

High

1453871

XPO7
Exportin-7

1

7

High-throughput

0.479

High

1453873

AGO2
Protein argonaute-2

1

11

High-throughput

0.479

High

1453874

AGO1
Protein argonaute-1

1

11

High-throughput

0.479

High

1453879

DTNA
Dystrobrevin alpha

1

10

High-throughput

0.479

High

1385895

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

689928

HGFL
Hepatocyte growth factor-like protein

1

1

Small-scale

0.457

High

208406

RRP8
Ribosomal RNA-processing protein 8

1

1

High-throughput

0.445

High

594121

NCK1
SH2/SH3 adapter protein NCK1

1

5

High-throughput

0.445

High

1023903

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

7

High-throughput

0.445

High

1288935

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

4

High-throughput

0.445

High

1352136

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

11

High-throughput

0.445

High

1396489

Q96KY9
CDH19 protein

1

12

High-throughput

0.445

High

1417622

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

6

High-throughput

0.445

High

49404

DHR12
Dehydrogenase/reductase SDR family member 12

1

2

High-throughput

0.437

High

106769

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

176563

GRRE1
Granule associated Rac and RHOG effector protein 1

1

3

High-throughput

0.437

High

273721

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

5

High-throughput

0.437

High

1381984

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.437

High

1451806

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.426

High

1258600

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

8

High-throughput

0.407

High

1148664

SF3A2
Splicing factor 3A subunit 2

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025