HitPredict

Interactor 1: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Interactor 2: MKNK1 (Q9BUB5)
MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1)
Gene: MKNK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2442 Hs			1 465
+	Hs
		625532 CBP_HUMAN (1-2442): 0: 1104: 100.00		CDK2_HUMAN (45-380): 9.09e-110: 328: 18.68
+	Hs
		1073459 CBP_HUMAN (1-2442): 0: 1104: 100.00		KS6A1_HUMAN (23-422): 1.9e-45: 170: 31.77
+	Hs
		850689 CBP_HUMAN (1-2442): 0: 1104: 100.00		KS6A3_HUMAN (43-452): 4.55e-43: 163: 30.41
+	Mm
		101422 F8VPR5_MOUSE (1-2442): 0: 1077: 95.67		KS6A3_MOUSE (43-452): 5.06e-43: 163: 30.41
+	Hs
		625393 EP300_HUMAN (1-2426): 0: 874: 55.06		CDK2_HUMAN (45-380): 9.09e-110: 328: 18.68
+	Hs
		270431 CBP_HUMAN (1-2442): 0: 1104: 100.00		KS6A5_HUMAN (53-404): 8.02e-20: 94.7: 25.75
+	Hs
		1071667 CBP_HUMAN (1-2442): 0: 1104: 100.00		KS6A2_HUMAN (41-373): 7e-19: 91.7: 26.32
+	Hs
		270406 EP300_HUMAN (1-2426): 0: 874: 55.06		KS6A5_HUMAN (53-404): 8.02e-20: 94.7: 25.75
+	Hs
		1356278 TRI33_HUMAN (694-1207): 3.25e-37: 156: 14.83		KS6A6_HUMAN (41-368): 1.23e-18: 90.9: 26.21