HitPredict

Interactor 1: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Interactor 2: DYR1B (Q9Y463)
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase)
Gene: DYRK1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	32707033, 23602568
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2442 Hs			1 629
+	Hs
		1044010 CBP_HUMAN (1-2442): 0: 1104: 100.00		DYR1A_HUMAN (19-594): 3.53e-135: 415: 63.57
+	Hs
		681959 CBP_HUMAN (1-2442): 0: 1104: 100.00		AKT1_HUMAN (6-429): 7.87e-119: 363: 18.41
+	Hs
		625532 CBP_HUMAN (1-2442): 0: 1104: 100.00		CDK2_HUMAN (108-376): 5.32e-119: 357: 27.82
+	Hs
		999248 EP300_HUMAN (1-2426): 0: 874: 55.06		DYR1B_HUMAN (1-629): 2.33e-171: 503: 100.00
+	Hs
		1206218 CBP_HUMAN (1-2442): 0: 1104: 100.00		HIPK1_HUMAN (111-434): 9.61e-55: 203: 37.17
+	Hs
		1270794 CBP_HUMAN (1-2442): 0: 1104: 100.00		HIPK3_HUMAN (111-430): 4.99e-53: 198: 37.09
+	Hs
		1270792 CBP_HUMAN (1-2442): 0: 1104: 100.00		HIPK2_HUMAN (111-434): 3.93e-52: 196: 36.31
+	Hs
		998682 EP300_HUMAN (1-2426): 0: 874: 55.06		DYR1A_HUMAN (19-594): 3.53e-135: 415: 63.57
+	At
		1105682 HAC1_ARATH (677-1887): 0: 897: 24.22		KSG7_ARATH (111-475): 9.76e-115: 349: 27.11
+	Hs
		681812 EP300_HUMAN (1-2426): 0: 874: 55.06		AKT1_HUMAN (6-429): 7.87e-119: 363: 18.41
+	Hs
		414892 EP300_HUMAN (1-2426): 0: 874: 55.06		CDK1_HUMAN (108-434): 4.87e-121: 362: 27.76
+	Hs
		625393 EP300_HUMAN (1-2426): 0: 874: 55.06		CDK2_HUMAN (108-376): 5.32e-119: 357: 27.82
+	Hs
		999086 EP300_HUMAN (1-2426): 0: 874: 55.06		HIPK2_HUMAN (111-434): 3.93e-52: 196: 36.31
+	Hs
		170273 TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97		AKT1_HUMAN (6-429): 7.87e-119: 363: 18.41
+	Hs
		1044321 PCLO_HUMAN (1952-2441): 8.89e-13: 76.8: 9.55		DYR1A_HUMAN (19-594): 3.53e-135: 415: 63.57
+	Ce
		712271 CBP1_CAEEL (94-860): 3.49e-12: 74.8: 16.69		MBK1_CAEEL (30-499): 2.63e-122: 385: 51.90