Protein: MICU2
Calcium uptake protein 2, mitochondrial (hMICU3) (EF-hand domain-containing family member A1)

Gene: MICU2
Organism: Homo sapiens
Interactions: 98
UniProt ID: Q8IYU8

Gene Ontology (top 5):
GO:0005246 - calcium channel regulator activity
GO:0005509 - calcium ion binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005758 - mitochondrial intermembrane space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1315597

MICU1
Calcium uptake protein 1, mitochondrial

7

14

Small-scale

0.743

High

251235

RNBP6
Ran-binding protein 6

2

1

High-throughput

0.628

High

349688

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

1

High-throughput

0.628

High

749789

CADH5
Cadherin-5

2

2

High-throughput

0.628

High

1199577

KLH22
Kelch-like protein 22

4

3

High-throughput

0.627

High

1315580

MCU
Calcium uniporter protein, mitochondrial

3

2

Small-scale

0.624

High

184067

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

3

1

High-throughput

0.609

High

885836

KC1E
Casein kinase I isoform epsilon

3

18

High-throughput

0.609

High

1135442

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

3

12

High-throughput

0.609

High

1315584

TB22A
TBC1 domain family member 22A

3

8

High-throughput

0.609

High

690587

PON1
Serum paraoxonase/arylesterase 1

2

0

High-throughput

0.602

High

348606

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

4

High-throughput

0.584

High

1315603

SFXN1
Sideroflexin-1

2

5

High-throughput

0.584

High

334208

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

2

1

High-throughput

0.574

High

845073

EAA3
Excitatory amino acid transporter 3

2

1

High-throughput

0.574

High

1315583

DCA11
DDB1- and CUL4-associated factor 11

2

2

High-throughput

0.574

High

1315590

TRI44
Tripartite motif-containing protein 44

2

1

High-throughput

0.574

High

1315608

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

2

1

High-throughput

0.558

High

848519

MAGA8
Melanoma-associated antigen 8

2

4

High-throughput

0.549

High

1197821

S39AC
Zinc transporter ZIP12

2

2

High-throughput

0.549

High

238721

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

6

High-throughput

0.536

High

1278170

PK1L2
Polycystin-1-like protein 2

1

5

High-throughput

0.536

High

1315576

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

2

High-throughput

0.536

High

1315579

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

1

High-throughput

0.536

High

1315582

HUMMR
Protein MGARP

1

2

High-throughput

0.536

High

1113650

CUL3
Cullin-3

2

4

High-throughput

0.533

High

396479

ESR1
Estrogen receptor

2

6

High-throughput

0.521

High

877168

KC1D
Casein kinase I isoform delta

2

19

High-throughput

0.521

High

182649

GP182
G-protein coupled receptor 182

1

4

High-throughput

0.489

High

457544

TBB5
Tubulin beta chain

1

1

High-throughput

0.489

High

848282

MAGA3
Melanoma-associated antigen 3

1

4

High-throughput

0.489

High

956934

CXCR4
C-X-C chemokine receptor type 4

1

3

High-throughput

0.489

High

976835

LCN6
Epididymal-specific lipocalin-6

1

3

High-throughput

0.489

High

977751

ACTA
Actin, aortic smooth muscle

1

1

High-throughput

0.489

High

1145491

RBBP5
Retinoblastoma-binding protein 5

1

2

High-throughput

0.489

High

1198417

LRC23
Leucine-rich repeat-containing protein 23

1

5

High-throughput

0.489

High

1251376

GGYF2
GRB10-interacting GYF protein 2

1

2

High-throughput

0.489

High

1270837

SV2A
Synaptic vesicle glycoprotein 2A

1

6

High-throughput

0.489

High

1315581

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

1315588

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.489

High

1315600

YTHD1
YTH domain-containing family protein 1

1

1

High-throughput

0.489

High

216746

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.479

High

242243

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

245494

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

1

High-throughput

0.479

High

292168

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

12

High-throughput

0.479

High

296266

SCO1
Protein SCO1 homolog, mitochondrial

1

5

High-throughput

0.479

High

560012

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

3

High-throughput

0.479

High

754907

H2B1B
Histone H2B type 1-B

1

1

High-throughput

0.479

High

1013416

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

2

High-throughput

0.479

High

1162417

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.479

High

1315586

AKAP1
A-kinase anchor protein 1, mitochondrial

1

3

High-throughput

0.479

High

1315587

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1315591

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

2

High-throughput

0.479

High

1315594

IMP1L
Mitochondrial inner membrane protease subunit 1

1

6

High-throughput

0.479

High

1315595

IMP2L
Mitochondrial inner membrane protease subunit 2

1

6

High-throughput

0.479

High

1315596

PHB2
Prohibitin-2

1

8

High-throughput

0.479

High

1315598

MIC26
MICOS complex subunit MIC26

1

4

High-throughput

0.479

High

1315601

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

16

High-throughput

0.479

High

1315602

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

4

High-throughput

0.479

High

1315607

DBLOH
Diablo IAP-binding mitochondrial protein

1

2

High-throughput

0.479

High

508263

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.457

High

430118

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

1107911

SQSTM
Sequestosome-1

1

3

High-throughput

0.445

High

1315589

GASP2
G-protein coupled receptor-associated sorting protein 2

1

1

High-throughput

0.439

High

293992

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.437

High

537490

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.437

High

589124

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

695908

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

768616

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1254575

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1315592

SNX27
Sorting nexin-27

1

9

High-throughput

0.437

High

1315605

BRD7
Bromodomain-containing protein 7

1

4

High-throughput

0.437

High

1315606

ANLN
Anillin

1

3

High-throughput

0.437

High

1315609

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.437

High

1315610

ARI1
E3 ubiquitin-protein ligase ARIH1

1

6

High-throughput

0.437

High

1251155

ZNT10
Calcium/manganese antiporter SLC30A10

1

2

High-throughput

0.407

High

1271241

SV2B
Synaptic vesicle glycoprotein 2B

1

9

High-throughput

0.407

High

1311138

UBR2
E3 ubiquitin-protein ligase UBR2

1

1

High-throughput

0.407

High

1315573

S22AF
Solute carrier family 22 member 15

1

2

High-throughput

0.407

High

1315575

S22AO
Steroid transmembrane transporter SLC22A24

1

2

High-throughput

0.407

High

1315611

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

2

High-throughput

0.407

High

1314744

SMAP1
Stromal membrane-associated protein 1

3

0

High-throughput

0.347

High

1315604

SACA1
Sperm acrosome membrane-associated protein 1

3

0

High-throughput

0.347

High

1239237

ARMC6
Armadillo repeat-containing protein 6

2

0

High-throughput

0.328

High

1281172

CPLX4
Complexin-4

2

0

High-throughput

0.328

High

380314

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

0

High-throughput

0.279

Low

600556

ZSC20
Zinc finger and SCAN domain-containing protein 20

1

0

High-throughput

0.279

Low

600623

NAGAB
Alpha-N-acetylgalactosaminidase

1

0

High-throughput

0.279

Low

720507

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.279

Low

1199916

P5CR3
Pyrroline-5-carboxylate reductase 3

1

0

High-throughput

0.279

Low

1307343

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

0

High-throughput

0.279

Low

1315574

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.279

Low

1315577

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

0

High-throughput

0.279

Low

1315585

AQP3
Aquaporin-3

1

0

High-throughput

0.279

Low

1315593

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.279

Low

1315599

ASHWN
Ashwin

1

0

High-throughput

0.279

Low

1213001

SKT
Sickle tail protein homolog

1

0

High-throughput

0.249

Low

1315578

CD177
CD177 antigen

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025