HitPredict

Interactor 1: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	14691252, 28680062
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0008270 - zinc ion binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2442 Hs			1 628
+	Hs
		278139 CBP_HUMAN (1-2442): 0: 1104: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278313 CBP_HUMAN (1-2442): 0: 1104: 100.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		999269 EP300_HUMAN (1-2426): 0: 874: 55.06		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		278068 EP300_HUMAN (1-2426): 0: 874: 55.06		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		170420 TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		1067047 BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	At
		1147337 GTE3_ARATH (1093-1371): 1.09e-52: 195: 18.41		SIZ1_ARATH (5-623): 1.75e-120: 380: 21.29
+	At
		1147329 GTE5_ARATH (964-1370): 5.66e-43: 167: 15.60		SIZ1_ARATH (5-623): 1.75e-120: 380: 21.29