Protein: HELLS
Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)

Gene: HELLS
Organism: Homo sapiens
Interactions: 196
UniProt ID: Q9NRZ9

Gene Ontology (top 5):
GO:0000775 - chromosome, centromeric region
GO:0001655 - urogenital system development
GO:0001822 - kidney development
GO:0003682 - chromatin binding
GO:0004386 - helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1436806

WDR76
WD repeat-containing protein 76

6

20

Small-scale

0.953

High

998851

H31
Histone H3.1

3

20

High-throughput

0.827

High

981126

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.754

High

1215372

DCAF8
DDB1- and CUL4-associated factor 8

1

20

Small-scale

0.747

High

685073

DNMT1
DNA

1

20

Small-scale

0.724

High

1449043

DNM3B
DNA

1

10

Small-scale

0.724

High

129811

CBX4
E3 SUMO-protein ligase CBX4

1

20

High-throughput

0.691

High

1340676

NEDD1
Protein NEDD1

1

16

High-throughput

0.691

High

346386

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

20

High-throughput

0.675

High

1449037

S39A9
Zinc transporter ZIP9

3

2

High-throughput

0.662

High

373255

MYC
Myc proto-oncogene protein

3

20

High-throughput

0.656

High

487794

PARP1
Poly [ADP-ribose] polymerase 1

3

20

Small-scale

0.640

High

1368145

HDAC2
Histone deacetylase 2

3

20

Small-scale

0.640

High

596379

H12
Histone H1.2

2

10

Small-scale

0.624

High

1110116

HDAC1
Histone deacetylase 1

2

20

Small-scale

0.624

High

580842

PVR
Poliovirus receptor

1

1

High-throughput

0.618

High

277830

H2AY
Core histone macro-H2A.1

1

20

Small-scale

0.618

High

883702

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

954012

IF4A1
Eukaryotic initiation factor 4A-I

1

16

Small-scale

0.618

High

980403

H4
Histone H4

1

19

High-throughput

0.618

High

1017239

H33
Histone H3.3

1

20

High-throughput

0.618

High

1042932

ERCC6
DNA excision repair protein ERCC-6

1

18

Small-scale

0.618

High

1097586

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.618

High

1132999

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

17

High-throughput

0.618

High

1380192

FBXW7
F-box/WD repeat-containing protein 7

1

13

High-throughput

0.618

High

1414583

DDX23
Probable ATP-dependent RNA helicase DDX23

1

20

High-throughput

0.618

High

1433849

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

15

High-throughput

0.618

High

1449036

HELLS
Lymphoid-specific helicase

1

18

Small-scale

0.618

High

562430

LAMP2
Lysosome-associated membrane glycoprotein 2

3

1

High-throughput

0.613

High

1121170

SRTD2
SERTA domain-containing protein 2

2

0

High-throughput

0.580

High

821776

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

0

High-throughput

0.578

High

907596

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

Small-scale

0.578

High

366266

FA9
Coagulation factor IX

2

5

High-throughput

0.574

High

1159115

C3AR
C3a anaphylatoxin chemotactic receptor

2

3

High-throughput

0.574

High

143478

E2F3
Transcription factor E2F3

1

9

Small-scale

0.569

High

414697

P53
Cellular tumor antigen p53

1

10

Small-scale

0.561

High

1403660

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

19

Small-scale

0.561

High

1431096

GTSFL
Gametocyte-specific factor 1-like

2

1

High-throughput

0.553

High

302976

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

20

High-throughput

0.553

High

1255719

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.553

High

182791

GP182
G-protein coupled receptor 182

2

3

High-throughput

0.549

High

74621

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

14

High-throughput

0.536

High

133133

FOXE1
Forkhead box protein E1

1

20

High-throughput

0.536

High

484228

PGFRB
Platelet-derived growth factor receptor beta

1

10

High-throughput

0.536

High

535584

BIP
Endoplasmic reticulum chaperone BiP

1

13

High-throughput

0.536

High

682625

S100P
Protein S100-P

1

11

High-throughput

0.536

High

848571

MAGA8
Melanoma-associated antigen 8

1

8

High-throughput

0.536

High

848727

MAGA9
Melanoma-associated antigen 9

1

8

High-throughput

0.536

High

937656

FOXG1
Forkhead box protein G1

1

20

High-throughput

0.536

High

938030

FOXA3
Hepatocyte nuclear factor 3-gamma

1

20

High-throughput

0.536

High

1091355

FOXL1
Forkhead box protein L1

1

20

High-throughput

0.536

High

1111297

SNW1
SNW domain-containing protein 1

1

9

High-throughput

0.536

High

1134745

NUMA1
Nuclear mitotic apparatus protein 1

1

18

High-throughput

0.536

High

1150258

TEAD2
Transcriptional enhancer factor TEF-4

1

8

High-throughput

0.536

High

1395773

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

6

High-throughput

0.536

High

1402717

TCPQM
T-complex protein 1 subunit theta-like 2

1

7

High-throughput

0.536

High

1404437

CDC5L
Cell division cycle 5-like protein

1

20

High-throughput

0.536

High

1420503

FOXQ1
Forkhead box protein Q1

1

20

High-throughput

0.536

High

1449050

TPX2
Targeting protein for Xklp2

1

2

High-throughput

0.536

High

1449046

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

5

High-throughput

0.515

High

280839

PR40A
Pre-mRNA-processing factor 40 homolog A

1

20

High-throughput

0.515

High

937119

CASP6
Caspase-6

1

5

High-throughput

0.515

High

981714

RAN
GTP-binding nuclear protein Ran

1

11

High-throughput

0.515

High

1232599

Q6FHY5
MEOX2 protein

1

6

High-throughput

0.515

High

1227531

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.514

High

1420229

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

423275

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

209117

CYB5B
Cytochrome b5 type B

1

3

High-throughput

0.489

High

488873

FURIN
Furin

1

1

High-throughput

0.489

High

706328

S10A2
Protein S100-A2

1

11

High-throughput

0.489

High

1136382

EMC2
ER membrane protein complex subunit 2

1

8

High-throughput

0.489

High

1142189

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

1270855

SV2A
Synaptic vesicle glycoprotein 2A

1

2

High-throughput

0.489

High

1383869

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.489

High

1407304

CML1
Chemerin-like receptor 1

1

3

High-throughput

0.489

High

1420850

SEM4C
Semaphorin-4C

1

4

High-throughput

0.489

High

1449040

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

1

High-throughput

0.489

High

1449042

VAPA
Vesicle-associated membrane protein-associated protein A

1

3

High-throughput

0.489

High

1449049

ANR50
Ankyrin repeat domain-containing protein 50

1

5

High-throughput

0.489

High

894193

MEOX2
Homeobox protein MOX-2

1

6

High-throughput

0.481

High

48391

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

3

Small-scale

0.479

High

168332

HAT1
Histone acetyltransferase type B catalytic subunit

1

3

Small-scale

0.479

High

243055

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

254438

CC14B
Dual specificity protein phosphatase CDC14B

1

4

High-throughput

0.479

High

260509

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

294393

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

298452

DNJC8
DnaJ homolog subfamily C member 8

1

8

High-throughput

0.479

High

363911

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

386275

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.479

High

404460

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

412671

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.479

High

521966

H14
Histone H1.4

1

10

Small-scale

0.479

High

558436

XRCC6
X-ray repair cross-complementing protein 6

1

13

Small-scale

0.479

High

566056

EF2
Elongation factor 2

1

11

Small-scale

0.479

High

573264

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.479

High

589804

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

595611

H15
Histone H1.5

1

14

Small-scale

0.479

High

595887

H13
Histone H1.3

1

10

Small-scale

0.479

High

607146

CEBPB
CCAAT/enhancer-binding protein beta

1

20

High-throughput

0.479

High

634658

LMNB1
Lamin-B1

1

20

High-throughput

0.479

High

644087

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

7

High-throughput

0.479

High

647668

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

3

Small-scale

0.479

High

696621

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

12

High-throughput

0.479

High

697267

APEX1
DNA repair nuclease/redox regulator APEX1

1

4

High-throughput

0.479

High

714448

PML
Protein PML

1

18

High-throughput

0.479

High

731637

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

787085

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

9

High-throughput

0.479

High

800121

COIL
Coilin

1

9

High-throughput

0.479

High

831496

CCNF
Cyclin-F

1

9

High-throughput

0.479

High

848445

MAGA6
Melanoma-associated antigen 6

1

8

High-throughput

0.479

High

853532

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

16

Small-scale

0.479

High

895803

LHX2
LIM/homeobox protein Lhx2

1

12

High-throughput

0.479

High

916359

TXTP
Tricarboxylate transport protein, mitochondrial

1

5

High-throughput

0.479

High

920898

ACLY
ATP-citrate synthase

1

3

Small-scale

0.479

High

935178

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

957678

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

2

Small-scale

0.479

High

957849

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

1

Small-scale

0.479

High

996027

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

1

Small-scale

0.479

High

1008374

PRKDC
DNA-dependent protein kinase catalytic subunit

1

15

Small-scale

0.479

High

1037397

H11
Histone H1.1

1

10

Small-scale

0.479

High

1067755

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

1114408

CUL3
Cullin-3

1

13

High-throughput

0.479

High

1115087

CUL4A
Cullin-4A

1

13

Small-scale

0.479

High

1115454

CUL4B
Cullin-4B

1

13

Small-scale

0.479

High

1138675

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

11

High-throughput

0.479

High

1140919

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

1141327

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

1155813

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.479

High

1157951

DDB1
DNA damage-binding protein 1

1

8

Small-scale

0.479

High

1218572

MYSM1
Deubiquitinase MYSM1

1

20

Small-scale

0.479

High

1276844

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

14

High-throughput

0.479

High

1289653

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.479

High

1290983

TAXB1
Tax1-binding protein 1

1

15

High-throughput

0.479

High

1313458

SMC5
Structural maintenance of chromosomes protein 5

1

16

High-throughput

0.479

High

1316889

ASPM
Abnormal spindle-like microcephaly-associated protein

1

4

High-throughput

0.479

High

1338389

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

1361246

DNJC9
DnaJ homolog subfamily C member 9

1

6

High-throughput

0.479

High

1363639

H1X
Histone H1.10

1

2

Small-scale

0.479

High

1380663

FBX32
F-box only protein 32

1

2

High-throughput

0.479

High

1397468

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

1402606

SRPK1
SRSF protein kinase 1

1

9

Small-scale

0.479

High

1433446

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.479

High

1449039

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

6

High-throughput

0.479

High

1449041

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

1

Small-scale

0.479

High

1449045

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1449047

TEKT2
Tektin-2

1

2

High-throughput

0.479

High

1449051

FZR1
Fizzy-related protein homolog

1

17

High-throughput

0.479

High

1449052

SMC3
Structural maintenance of chromosomes protein 3

1

12

High-throughput

0.479

High

1449053

ZN330
Zinc finger protein 330

1

7

High-throughput

0.479

High

329170

RCBT2
RCC1 and BTB domain-containing protein 2

1

2

High-throughput

0.470

High

983988

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

1313057

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

231641

PRKY
Putative serine/threonine-protein kinase PRKY

1

5

High-throughput

0.445

High

621531

HXK1
Hexokinase-1

1

1

High-throughput

0.445

High

896460

ERF
ETS domain-containing transcription factor ERF

1

20

High-throughput

0.445

High

1209703

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1391794

AURKB
Aurora kinase B

1

5

High-throughput

0.445

High

191117

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

13

High-throughput

0.437

High

583898

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

1

Small-scale

0.437

High

769288

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

886327

ARL4D
ADP-ribosylation factor-like protein 4D

1

7

High-throughput

0.437

High

985017

RL31
Large ribosomal subunit protein eL31

1

4

High-throughput

0.437

High

1071195

ARL16
ADP-ribosylation factor-like protein 16

1

6

High-throughput

0.437

High

1295580

MIB1
E3 ubiquitin-protein ligase MIB1

1

6

High-throughput

0.437

High

1314436

SLX4
Structure-specific endonuclease subunit SLX4

1

14

High-throughput

0.437

High

1430594

CCDC8
Coiled-coil domain-containing protein 8

1

4

High-throughput

0.437

High

1431547

VP33B
Vacuolar protein sorting-associated protein 33B

1

2

High-throughput

0.437

High

1433997

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

1435177

RPAP3
RNA polymerase II-associated protein 3

1

12

High-throughput

0.437

High

1438177

RHOF
Rho-related GTP-binding protein RhoF

1

2

High-throughput

0.437

High

1449038

DJC17
DnaJ homolog subfamily C member 17

1

13

High-throughput

0.437

High

1449048

TF3C4
General transcription factor 3C polypeptide 4

1

2

Small-scale

0.437

High

887253

CEBPA
CCAAT/enhancer-binding protein alpha

1

19

High-throughput

0.408

High

638530

FPR1
fMet-Leu-Phe receptor

1

3

High-throughput

0.407

High

1239310

ARMC6
Armadillo repeat-containing protein 6

1

2

High-throughput

0.407

High

1271274

SV2B
Synaptic vesicle glycoprotein 2B

1

2

High-throughput

0.407

High

1366260

LPAR1
Lysophosphatidic acid receptor 1

1

2

High-throughput

0.407

High

1412072

S39A3
Zinc transporter ZIP3

1

2

High-throughput

0.407

High

1431261

DJC25
DnaJ homolog subfamily C member 25

1

5

High-throughput

0.407

High

1446073

S39A2
Zinc transporter ZIP2

1

2

High-throughput

0.407

High

1449054

ASB4
Ankyrin repeat and SOCS box protein 4

1

6

High-throughput

0.407

High

332712

LYPD3
Ly6/PLAUR domain-containing protein 3

3

0

High-throughput

0.347

High

1287185

T150A
Transmembrane protein 150A

2

0

High-throughput

0.318

High

1358027

TM171
Transmembrane protein 171

2

0

High-throughput

0.318

High

317090

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

0

High-throughput

0.279

Low

388308

GLPA
Glycophorin-A

1

0

High-throughput

0.279

Low

1213716

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

1387673

NXPE2
NXPE family member 2

1

0

High-throughput

0.279

Low

1437175

CHODL
Chondrolectin

1

0

High-throughput

0.279

Low

1449044

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

441566

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

85314

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

Small-scale

0.249

Low

1249248

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1258080

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low

1310960

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025