HitPredict

Interactor 1: CSN5 (Q92905)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
Gene: COPS5

Interactor 2: BRWD1 (Q9NSI6)
Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9)
Gene: BRWD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	35914814, 21145461
Identification Methods	two hybrid, affinity chromatography technology, tandem affinity purification, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 2320
+	Hs
		1262794 CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00		PHIP_HUMAN (5-1763): 0: 1192: 51.13
+	Hs
		903414 CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00		WDR5_HUMAN (399-710): 1.44e-45: 170: 12.38
+	Hs
		130829 PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51		WDR5_HUMAN (399-710): 1.44e-45: 170: 12.38
+	Hs
		124920 EIF3F_HUMAN (44-328): 3.25e-64: 208: 14.48		FBXW7_HUMAN (409-747): 3.31e-46: 181: 12.35
+	Hs
		124819 EIF3F_HUMAN (44-328): 3.25e-64: 208: 14.48		WDR5_HUMAN (399-710): 1.44e-45: 170: 12.38
+	Hs
		1138819 MYSM1_HUMAN (39-172): 3.5e-29: 119: 23.29		SNR40_HUMAN (28-212): 6.57e-30: 125: 12.63