HitPredict

Interactor 1: KCNB2 (Q92953)
Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2)
Gene: KCNB2

Interactor 2: KCNF1 (Q9H3M0)
Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1)
Gene: KCNF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BTB_2~BTB_2, Ion_trans~Ion_trans
Common GO terms	GO:0005886 - plasma membrane GO:0006813 - potassium ion transport GO:0008076 - voltage-gated potassium channel complex GO:0051260 - protein homooligomerization GO:0071805 - potassium ion transmembrane transport
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 911 Hs			1 494
+	Hs
		1058645 KCNB2_HUMAN (1-911): 0: 738: 100.00		KCNB1_HUMAN (1-443): 1.83e-134: 411: 40.85
+	Hs
		1273152 KCNB2_HUMAN (1-911): 0: 738: 100.00		KCNB2_HUMAN (9-456): 4.08e-134: 411: 39.87
+	Mm
		61654 KCNB2_MOUSE (1-911): 0: 728: 92.65		KCNB1_MOUSE (1-443): 3.9e-134: 410: 40.85
+	Hs
		1255150 KCNB2_HUMAN (1-911): 0: 738: 100.00		KCNG4_HUMAN (12-431): 1.12e-114: 349: 33.87
+	Hs
		1273155 KCNB2_HUMAN (1-911): 0: 738: 100.00		KCNS3_HUMAN (17-418): 1.3e-110: 338: 37.11
+	Hs
		1273162 KCNB2_HUMAN (1-911): 0: 738: 100.00		KCNG1_HUMAN (5-436): 3.04e-101: 314: 33.78
+	Hs
		1161871 KCNB2_HUMAN (1-911): 0: 738: 100.00		KCNV1_HUMAN (11-476): 3.13e-99: 309: 32.50
+	Hs
		1058633 KCNB1_HUMAN (6-911): 0: 616: 62.06		KCNB1_HUMAN (1-443): 1.83e-134: 411: 40.85
+	Hs
		1251106 KCNB2_HUMAN (1-911): 0: 738: 100.00		KCNG3_HUMAN (15-415): 8.27e-69: 228: 34.67
+	Hs
		1058643 KCNB1_HUMAN (6-911): 0: 616: 62.06		KCNG4_HUMAN (12-431): 1.12e-114: 349: 33.87
+	Hs
		1058647 KCNB1_HUMAN (6-911): 0: 616: 62.06		KCNS3_HUMAN (17-418): 1.3e-110: 338: 37.11
+	Hs
		1058644 KCNB1_HUMAN (6-911): 0: 616: 62.06		KCNV2_HUMAN (2-445): 4.95e-101: 315: 35.21
+	Hs
		1058649 KCNB1_HUMAN (6-911): 0: 616: 62.06		KCNG1_HUMAN (5-436): 3.04e-101: 314: 33.78
+	Hs
		1058636 KCNB1_HUMAN (6-911): 0: 616: 62.06		KCNV1_HUMAN (11-476): 3.13e-99: 309: 32.50
+	Hs
		1058642 KCNB1_HUMAN (6-911): 0: 616: 62.06		KCNG3_HUMAN (15-415): 8.27e-69: 228: 34.67
+	Hs
		569033 KCNA6_HUMAN (35-433): 2.12e-164: 492: 34.35		KCNA3_HUMAN (6-466): 1.43e-109: 338: 28.75
+	Hs
		608299 KCND3_HUMAN (1-655): 5.02e-146: 449: 26.62		KCNA5_HUMAN (11-477): 2.77e-105: 328: 26.47
+	Hs
		558790 KCNQ5_HUMAN (140-900): 7.53e-135: 428: 17.50		KCNA2_HUMAN (2-451): 5.43e-109: 334: 27.58