Protein: JHD2C
Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8)

Gene: JHD2C, JMJD1C
Organism: Homo sapiens
Interactions: 85
UniProt ID: Q15652

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000785 - chromatin
GO:0003712 - transcription coregulator activity
GO:0005654 - nucleoplasm
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

520080

ANDR
Androgen receptor

3

10

Small-scale

0.661

High

372119

MYC
Myc proto-oncogene protein

3

2

High-throughput

0.640

High

1151457

PF21A
PHD finger protein 21A

1

0

High-throughput

0.586

High

1054716

SUH
Recombining binding protein suppressor of hairless

2

0

High-throughput

0.585

High

998354

H31
Histone H3.1

2

7

High-throughput

0.584

High

302534

RNF8
E3 ubiquitin-protein ligase RNF8

1

2

Small-scale

0.578

High

789505

PPARG
Peroxisome proliferator-activated receptor gamma

2

10

Small-scale

0.571

High

404080

GCR
Glucocorticoid receptor

2

11

Small-scale

0.563

High

1014106

CBX1
Chromobox protein homolog 1

1

5

High-throughput

0.536

High

1151440

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

474010

NFIC
Nuclear factor 1 C-type

1

7

High-throughput

0.515

High

1133426

NFIX
Nuclear factor 1 X-type

1

8

High-throughput

0.515

High

455780

H10
Histone H1.0

1

0

High-throughput

0.513

High

501998

H2AZ
Histone H2A.Z

1

0

High-throughput

0.513

High

1151448

RN168
E3 ubiquitin-protein ligase RNF168

1

0

Small-scale

0.505

High

1006425

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.501

High

1151455

ESR2
Estrogen receptor beta

1

10

Small-scale

0.501

High

916100

NKX25
Homeobox protein Nkx-2.5

1

1

High-throughput

0.500

High

334017

SMC2
Structural maintenance of chromosomes protein 2

1

0

High-throughput

0.493

High

228267

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.486

High

391700

MT2
Metallothionein-2

1

0

High-throughput

0.486

High

405467

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

665260

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

High-throughput

0.486

High

968710

PRS4
26S proteasome regulatory subunit 4

1

0

High-throughput

0.486

High

129117

MEN1
Menin

1

1

High-throughput

0.479

High

130477

SPT5H
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

143012

NFIB
Nuclear factor 1 B-type

1

7

High-throughput

0.479

High

323386

TRI37
E3 ubiquitin-protein ligase TRIM37

1

3

High-throughput

0.479

High

588787

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

695553

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

714148

PML
Protein PML

1

2

High-throughput

0.479

High

768280

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

862164

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.479

High

872363

SOX2
Transcription factor SOX-2

1

1

Small-scale

0.479

High

886891

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.479

High

980790

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

1016888

H33
Histone H3.3

1

7

High-throughput

0.479

High

1087758

NFIA
Nuclear factor 1 A-type

1

8

High-throughput

0.479

High

1088853

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1109755

HDAC1
Histone deacetylase 1

1

7

High-throughput

0.479

High

1151444

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1151447

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1151449

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.479

High

1151453

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

1151456

HDAC2
Histone deacetylase 2

1

7

High-throughput

0.479

High

1151458

SOX7
Transcription factor SOX-7

1

1

High-throughput

0.479

High

1151459

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.479

High

1151460

WWTR1
WW domain-containing transcription regulator protein 1

1

4

High-throughput

0.479

High

1151462

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1151465

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

270248

MTG16
Protein CBFA2T3

1

0

Small-scale

0.458

High

558164

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

822679

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

830802

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

944658

KLF3
Krueppel-like factor 3

1

0

High-throughput

0.458

High

979719

H4
Histone H4

1

0

High-throughput

0.458

High

1004608

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1129603

MDC1
Mediator of DNA damage checkpoint protein 1

1

0

Small-scale

0.458

High

1151441

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

1151443

BCOR
BCL-6 corepressor

1

0

Small-scale

0.458

High

1151445

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.458

High

1151446

THOC4
THO complex subunit 4

1

0

High-throughput

0.458

High

1151450

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1151464

CNOT2
CCR4-NOT transcription complex subunit 2

1

0

High-throughput

0.458

High

1151467

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

1151468

KLH20
Kelch-like protein 20

1

2

Small-scale

0.439

High

341576

EYA4
Protein phosphatase EYA4

1

1

High-throughput

0.437

High

378493

IL1A
Interleukin-1 alpha

1

1

Small-scale

0.437

High

1063274

GOGA2
Golgin subfamily A member 2

1

1

High-throughput

0.437

High

1151463

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

1

High-throughput

0.437

High

1151466

XPO7
Exportin-7

1

3

High-throughput

0.437

High

662578

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

Small-scale

0.426

High

928836

MYOM2
Myomesin-2

1

0

High-throughput

0.282

High

1144761

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

0

High-throughput

0.279

Low

247341

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.249

Low

337352

PARN
Poly(A)-specific ribonuclease PARN

1

0

High-throughput

0.249

Low

417454

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.249

Low

642892

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

732322

PRDX2
Peroxiredoxin-2

1

0

High-throughput

0.249

Low

1025917

NDP
Norrin

1

0

Small-scale

0.249

Low

1151442

FBX38
F-box only protein 38

1

0

High-throughput

0.249

Low

1151451

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.249

Low

1151452

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.249

Low

1151454

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.249

Low

1151461

TXNIP
Thioredoxin-interacting protein

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025