HitPredict

Interactor 1: USP9X (Q93008)
Ubiquitin carboxyl-terminal hydrolase 9X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)
Gene: USP9X

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	26508657, 17038327, 19341794
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0016567 - protein ubiquitination
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 2554 Hs			1 903
+	Hs
		1273724 USP9X_HUMAN (1-2554): 0: 3676: 100.00		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		125624 USP9X_HUMAN (1-2554): 0: 3676: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		1192153 USP9X_HUMAN (1-2554): 0: 3676: 100.00		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		1273741 USP9X_HUMAN (1-2554): 0: 3676: 100.00		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		1273751 USP9X_HUMAN (1-2554): 0: 3676: 100.00		HECW2_HUMAN (1-512): 1.38e-13: 77.2: 11.34
+	Hs
		125794 UBP24_HUMAN (36-2478): 0: 2211: 29.78		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		64219 UBP27_HUMAN (1524-1949): 2.29e-96: 321: 17.61		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		259303 UBP12_HUMAN (1519-1957): 8.45e-94: 311: 21.51		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		125625 UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		1273807 UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Mm
		1149452 UBP7_MOUSE (1469-2119): 1.12e-95: 339: 18.82		HUWE1_MOUSE (415-902): 1.58e-160: 523: 34.88
+	Hs
		1192154 UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		1176343 UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76