Protein: SMC4
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog)

Gene: SMC4
Organism: Homo sapiens
Interactions: 189
UniProt ID: Q9NTJ3

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000775 - chromosome, centromeric region
GO:0000794 - condensed nuclear chromosome
GO:0000796 - condensin complex
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

311633

SMC2
Structural maintenance of chromosomes protein 2

8

16

Small-scale

0.965

High

1062405

CND2
Condensin complex subunit 2

5

8

Small-scale

0.927

High

789354

CNDD3
Condensin-2 complex subunit D3

2

19

High-throughput

0.776

High

1152396

CNDH2
Condensin-2 complex subunit H2

4

3

Small-scale

0.699

High

348010

MYC
Myc proto-oncogene protein

4

14

High-throughput

0.694

High

1308614

CND3
Condensin complex subunit 3

4

10

Small-scale

0.686

High

370526

ESR1
Estrogen receptor

3

15

Small-scale

0.633

High

224536

RAD21
Double-strand-break repair protein rad21 homolog

1

20

High-throughput

0.618

High

1063378

CND1
Condensin complex subunit 1

1

19

Small-scale

0.618

High

244996

BRD4
Bromodomain-containing protein 4

2

7

High-throughput

0.584

High

504825

HSP7C
Heat shock cognate 71 kDa protein

2

3

High-throughput

0.584

High

553834

RFA2
Replication protein A 32 kDa subunit

2

4

High-throughput

0.584

High

652371

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

5

High-throughput

0.584

High

721563

RFA3
Replication protein A 14 kDa subunit

2

4

High-throughput

0.584

High

780178

CCNF
Cyclin-F

2

5

High-throughput

0.584

High

808962

YAP1
Transcriptional coactivator YAP1

2

6

Small-scale

0.584

High

973255

RL6
Large ribosomal subunit protein eL6

2

1

High-throughput

0.584

High

1116574

LARP7
La-related protein 7

2

4

High-throughput

0.584

High

1343670

ANLN
Anillin

2

4

High-throughput

0.584

High

1345723

HECD1
E3 ubiquitin-protein ligase HECTD1

2

9

Small-scale

0.584

High

1255320

MIPT3
TRAF3-interacting protein 1

2

6

High-throughput

0.539

High

126482

FOXE1
Forkhead box protein E1

1

17

High-throughput

0.536

High

149925

RFXK
DNA-binding protein RFXANK

1

12

High-throughput

0.536

High

199560

M3K13
Mitogen-activated protein kinase kinase kinase 13

1

7

High-throughput

0.536

High

270837

FOXH1
Forkhead box protein H1

1

18

High-throughput

0.536

High

277809

SERF1
Small EDRK-rich factor 1

1

1

High-throughput

0.536

High

529784

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.536

High

560311

DPEP1
Dipeptidase 1

1

1

High-throughput

0.536

High

789134

FRK
Tyrosine-protein kinase FRK

1

5

High-throughput

0.536

High

877640

FOXG1
Forkhead box protein G1

1

16

High-throughput

0.536

High

1021360

FOXL1
Forkhead box protein L1

1

15

High-throughput

0.536

High

1039879

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.536

High

1200412

ST32C
Serine/threonine-protein kinase 32C

1

4

High-throughput

0.536

High

1251929

RIN3
Ras and Rab interactor 3

1

4

High-throughput

0.536

High

1255602

NEK7
Serine/threonine-protein kinase Nek7

1

12

High-throughput

0.536

High

1284822

EFMT3
EEF1A lysine methyltransferase 3

1

7

High-throughput

0.536

High

1288036

HDA11
Histone deacetylase 11

1

13

High-throughput

0.536

High

1303788

CDC5L
Cell division cycle 5-like protein

1

6

High-throughput

0.536

High

1305412

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

14

High-throughput

0.536

High

1306870

FOXB1
Forkhead box protein B1

1

20

High-throughput

0.536

High

1318647

FOXQ1
Forkhead box protein Q1

1

20

High-throughput

0.536

High

1332024

SG196
Protein O-mannose kinase

1

1

High-throughput

0.536

High

1260783

DEP1B
DEP domain-containing protein 1B

2

2

High-throughput

0.521

High

548754

VAV
Proto-oncogene vav

1

7

High-throughput

0.515

High

639812

IKBA
NF-kappa-B inhibitor alpha

1

13

Small-scale

0.515

High

1045545

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

11

High-throughput

0.515

High

225058

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.513

High

311768

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

1318395

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1345722

INTU
Protein inturned

1

0

High-throughput

0.513

High

890859

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

High-throughput

0.501

High

902772

SUMO2
Small ubiquitin-related modifier 2

1

7

High-throughput

0.501

High

672743

CD6
T-cell differentiation antigen CD6

1

3

High-throughput

0.489

High

1067627

P2RY6
P2Y purinoceptor 6

1

4

High-throughput

0.489

High

1136845

FAXC
Failed axon connections homolog

1

1

High-throughput

0.489

High

1202562

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.489

High

1241918

ARRD4
Arrestin domain-containing protein 4

1

5

High-throughput

0.489

High

1328607

UN93B
Protein unc-93 homolog B1

1

3

High-throughput

0.489

High

1333230

IFT22
Intraflagellar transport protein 22 homolog

1

2

High-throughput

0.489

High

1345728

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

1

High-throughput

0.489

High

331343

CHK2
Serine/threonine-protein kinase Chk2

1

9

Small-scale

0.484

High

119536

LEG9
Galectin-9

1

5

High-throughput

0.479

High

123032

MEN1
Menin

1

4

High-throughput

0.479

High

149344

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

151213

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

3

High-throughput

0.479

High

210314

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

232996

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

7

High-throughput

0.479

High

303499

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

312095

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

6

Small-scale

0.479

High

323196

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

8

High-throughput

0.479

High

326788

SNAI1
Zinc finger protein SNAI1

1

9

High-throughput

0.479

High

351457

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

2

High-throughput

0.479

High

379920

MYCN
N-myc proto-oncogene protein

1

12

High-throughput

0.479

High

385587

NTRK1
High affinity nerve growth factor receptor

1

11

High-throughput

0.479

High

432296

HS90A
Heat shock protein HSP 90-alpha

1

8

High-throughput

0.479

High

570110

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

617682

CRCM
Colorectal mutant cancer protein

1

4

High-throughput

0.479

High

625610

CDK2
Cyclin-dependent kinase 2

1

8

High-throughput

0.479

High

685049

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

794144

MATR3
Matrin-3

1

4

High-throughput

0.479

High

807858

MAP1B
Microtubule-associated protein 1B

1

4

High-throughput

0.479

High

824429

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.479

High

828030

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

4

High-throughput

0.479

High

830298

CASP4
Caspase-4

1

4

High-throughput

0.479

High

841900

CDK9
Cyclin-dependent kinase 9

1

8

High-throughput

0.479

High

897834

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

909194

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

918010

H4
Histone H4

1

5

High-throughput

0.479

High

921747

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.479

High

961286

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

967984

PO5F1
POU domain, class 5, transcription factor 1

1

4

High-throughput

0.479

High

974684

MECOM
Histone-lysine N-methyltransferase MECOM

1

6

High-throughput

0.479

High

999132

EP300
Histone acetyltransferase p300

1

14

High-throughput

0.479

High

1029927

TIF1B
Transcription intermediary factor 1-beta

1

10

High-throughput

0.479

High

1032035

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

2

High-throughput

0.479

High

1036125

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

1036934

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1038754

HDAC1
Histone deacetylase 1

1

9

Small-scale

0.479

High

1042636

CUL3
Cullin-3

1

9

High-throughput

0.479

High

1049158

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.479

High

1050280

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

4

High-throughput

0.479

High

1063640

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

1064182

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

1064764

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1080392

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.479

High

1115760

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

1140800

RN123
E3 ubiquitin-protein ligase RNF123

1

4

High-throughput

0.479

High

1146878

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.479

High

1148809

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

1159303

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

1163880

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1167323

BCOR
BCL-6 corepressor

1

14

High-throughput

0.479

High

1174307

MOB3C
MOB kinase activator 3C

1

4

High-throughput

0.479

High

1184354

MEPCE
7SK snRNA methylphosphate capping enzyme

1

2

High-throughput

0.479

High

1188923

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1199697

ZN598
E3 ubiquitin-protein ligase ZNF598

1

5

High-throughput

0.479

High

1218765

GCC2
GRIP and coiled-coil domain-containing protein 2

1

8

High-throughput

0.479

High

1236524

SIR6
NAD-dependent protein deacylase sirtuin-6

1

5

Small-scale

0.479

High

1243958

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1246183

COP1
E3 ubiquitin-protein ligase COP1

1

2

High-throughput

0.479

High

1256422

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

1261422

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

1266887

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

Small-scale

0.479

High

1267183

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1269723

ESR2
Estrogen receptor beta

1

15

High-throughput

0.479

High

1274352

MED12
Mediator of RNA polymerase II transcription subunit 12

1

2

High-throughput

0.479

High

1281855

FBX32
F-box only protein 32

1

2

High-throughput

0.479

High

1289354

SPDLY
Protein Spindly

1

9

High-throughput

0.479

High

1303938

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.479

High

1304131

RING2
E3 ubiquitin-protein ligase RING2

1

11

High-throughput

0.479

High

1307010

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

1309067

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

1

High-throughput

0.479

High

1310518

RIOK1
Serine/threonine-protein kinase RIO1

1

5

High-throughput

0.479

High

1315512

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

7

High-throughput

0.479

High

1315878

FACD2
Fanconi anemia group D2 protein

1

9

High-throughput

0.479

High

1328262

CCDC8
Coiled-coil domain-containing protein 8

1

4

High-throughput

0.479

High

1328803

DUS15
Dual specificity protein phosphatase 15

1

3

High-throughput

0.479

High

1329165

AL8A1
2-aminomuconic semialdehyde dehydrogenase

1

1

High-throughput

0.479

High

1332665

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1334031

WDR76
WD repeat-containing protein 76

1

7

High-throughput

0.479

High

1336034

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.479

High

1342797

BRD7
Bromodomain-containing protein 7

1

12

High-throughput

0.479

High

1344492

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

1344569

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

1345715

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

1345717

MTMR4
Myotubularin-related protein 4

1

3

High-throughput

0.479

High

1345718

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

1345719

PD1L1
Programmed cell death 1 ligand 1

1

2

Small-scale

0.479

High

1345721

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1345724

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

1345725

CC14A
Dual specificity protein phosphatase CDC14A

1

11

High-throughput

0.479

High

1345726

TRI33
E3 ubiquitin-protein ligase TRIM33

1

11

High-throughput

0.479

High

1345729

NINL
Ninein-like protein

1

7

High-throughput

0.479

High

1345731

NEMO
NF-kappa-B essential modulator

1

11

High-throughput

0.479

High

1101620

MGAL
Probable maltase-glucoamylase 2

1

2

High-throughput

0.470

High

673524

MPIP2
M-phase inducer phosphatase 2

1

0

High-throughput

0.458

High

858340

TXTP
Tricarboxylate transport protein, mitochondrial

1

0

High-throughput

0.458

High

1030507

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

1314746

SF3B5
Splicing factor 3B subunit 5

1

0

High-throughput

0.458

High

1344729

SMYD2
N-lysine methyltransferase SMYD2

1

0

High-throughput

0.458

High

1345727

CBPC1
Cytosolic carboxypeptidase 1

1

0

High-throughput

0.458

High

402525

JUN
Transcription factor Jun

1

11

High-throughput

0.445

High

497659

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

632928

TYY1
Transcriptional repressor protein YY1

1

6

Small-scale

0.445

High

958777

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.445

High

1037412

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.445

High

1130639

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

1318866

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

1345720

DNM3B
DNA

1

1

Small-scale

0.445

High

541284

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

1

High-throughput

0.437

High

1048805

TRI29
Tripartite motif-containing protein 29

1

5

Small-scale

0.437

High

1165992

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1166874

LRC31
Leucine-rich repeat-containing protein 31

1

1

High-throughput

0.437

High

1171909

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1252508

LNX1
E3 ubiquitin-protein ligase LNX

1

1

Small-scale

0.437

High

1294046

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

1315157

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.437

High

1331404

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.437

High

1345714

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

48733

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.426

High

1233225

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

831723

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.408

High

1140

SIM26
Small integral membrane protein 26

1

2

High-throughput

0.407

High

1241640

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.407

High

1345716

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.279

Low

654826

CALX
Calnexin

1

0

High-throughput

0.249

Low

674271

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.249

Low

1239332

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1345730

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024