Interactor 1: UBP7 (Q93009)
Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)
Gene: USP7
Interactor 2: UHRF1 (Q96T88)
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)
Gene: UHRF1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.985 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26496610, 26299963, 26046769, 34094715, 34558642, 21745816, 21268065, 22411829, 28803780, 32884836, 36681316, 36593255, 23297342, 24013172 |
| Identification Methods | affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | UCH~ubiquitin |
| Common GO terms | GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0044027 - negative regulation of gene expression via chromosomal CpG island methylation |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
