HitPredict

Interactor 1: UBP7 (Q93009)
Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)
Gene: USP7

Interactor 2: SIR7 (Q9NRC8)
NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)
Gene: SIRT7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	28655758, 32711345, 22586326
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1102 Hs			1 400
+	Hs
		1236426 UBP7_HUMAN (1-1102): 0: 1165: 100.00		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1273784 UBP7_HUMAN (1-1102): 0: 1165: 100.00		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94
+	Hs
		1273923 UBP7_HUMAN (1-1102): 0: 1165: 100.00		SIR5_HUMAN (87-321): 1.97e-68: 220: 20.74
+	Mm
		1149461 UBP7_MOUSE (1-1102): 0: 1159: 99.00		SIR5_MOUSE (75-321): 9.3e-67: 216: 21.63
+	Hs
		1295908 UBP47_HUMAN (208-737): 3.48e-107: 368: 26.62		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1173882 UBP34_HUMAN (125-644): 3.97e-99: 348: 18.81		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1273745 USP9X_HUMAN (173-554): 7.42e-97: 341: 23.08		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1163948 U17L2_HUMAN (158-684): 1.09e-103: 338: 19.05		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1344537 UBP24_HUMAN (200-587): 2.93e-95: 337: 24.41		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1200159 UBP48_HUMAN (206-572): 1.45e-102: 349: 26.90		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1236425 USP9X_HUMAN (173-554): 7.42e-97: 341: 23.08		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1289478 UBP22_HUMAN (45-521): 2.51e-107: 347: 16.43		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94
+	Hs
		131661 USP9Y_HUMAN (186-564): 2.64e-96: 340: 22.64		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94