HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: KLDC3 (Q9BQ90)
Kelch domain-containing protein 3 (Testis intracellular mediator protein)
Gene: KLHDC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28514442, 18187417
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 382
+	Hs
		1041547 CUL3_HUMAN (8-780): 0: 754: 22.96		KEAP1_HUMAN (85-381): 2.76e-68: 228: 13.71
+	Mm
		1337550 CUL3_MOUSE (8-780): 0: 754: 22.96		KEAP1_MOUSE (85-381): 1.39e-66: 223: 14.00
+	Hs
		299529 CUL5_HUMAN (1-780): 0: 792: 100.00		KLH18_HUMAN (3-247): 6.9e-42: 156: 16.33
+	Hs
		1042324 CUL3_HUMAN (8-780): 0: 754: 22.96		KLHL5_HUMAN (110-381): 2.9e-53: 189: 14.64
+	Hs
		1042674 CUL3_HUMAN (8-780): 0: 754: 22.96		KLH28_HUMAN (2-247): 3.84e-47: 170: 15.04
+	Hs
		1042036 CUL3_HUMAN (8-780): 0: 754: 22.96		LZTR1_HUMAN (113-338): 6.82e-45: 167: 25.53
+	Hs
		299515 CUL3_HUMAN (8-780): 0: 754: 22.96		KLH18_HUMAN (3-247): 6.9e-42: 156: 16.33
+	Hs
		1041712 CUL3_HUMAN (8-780): 0: 754: 22.96		KLH12_HUMAN (1-191): 4.3e-40: 151: 18.33
+	Hs
		1042727 CUL3_HUMAN (8-780): 0: 754: 22.96		KLH13_HUMAN (140-381): 1.58e-39: 150: 15.39
+	Hs
		1042768 CUL3_HUMAN (8-780): 0: 754: 22.96		KLHL3_HUMAN (2-192): 1.78e-39: 149: 15.18
+	Hs
		1041807 CUL3_HUMAN (8-780): 0: 754: 22.96		KLH10_HUMAN (2-190): 6.04e-33: 131: 17.46
+	Mm
		1322059 CUL3_MOUSE (8-780): 0: 754: 22.96		KLH10_MOUSE (2-190): 7.05e-33: 131: 17.46
+	Hs
		1274086 CUL5_HUMAN (1-780): 0: 792: 100.00		KLDC2_HUMAN (3-149): 5.5e-19: 89.7: 22.37
+	Hs
		1042722 CUL3_HUMAN (8-780): 0: 754: 22.96		KLHL9_HUMAN (1-188): 2.78e-31: 127: 14.58
+	Hs
		1042489 CUL3_HUMAN (8-780): 0: 754: 22.96		KLHL4_HUMAN (2-137): 4.08e-24: 106: 16.06
+	Hs
		1042624 CUL3_HUMAN (8-780): 0: 754: 22.96		KLHL1_HUMAN (2-137): 1.42e-23: 104: 16.06
+	Hs
		1237057 CUL5_HUMAN (1-780): 0: 792: 100.00		KLDC1_HUMAN (237-340): 5.41e-10: 62.4: 21.43
+	Hs
		1042720 CUL3_HUMAN (8-780): 0: 754: 22.96		KLHL8_HUMAN (1-136): 8.04e-20: 93.2: 19.12
+	Hs
		848213 CUL3_HUMAN (8-780): 0: 754: 22.96		HCFC1_HUMAN (2-162): 3.19e-14: 76.6: 18.86
+	Hs
		276929 CUL3_HUMAN (8-780): 0: 754: 22.96		ATRN_HUMAN (4-108): 2.39e-09: 61.2: 23.85