Protein: PHF5A
PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b)

Gene: PHF5A
Organism: Homo sapiens
Interactions: 131
UniProt ID: Q7RTV0

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

285974

SF3B1
Splicing factor 3B subunit 1

8

1

Small-scale

0.968

High

1147930

SF3B3
Splicing factor 3B subunit 3

7

1

Small-scale

0.961

High

1274046

SF3B5
Splicing factor 3B subunit 5

3

1

High-throughput

0.861

High

1148608

SF3A2
Splicing factor 3A subunit 2

4

1

Small-scale

0.694

High

1274064

SF3B6
Splicing factor 3B subunit 6

3

2

Small-scale

0.670

High

471874

RU2B
U2 small nuclear ribonucleoprotein B''

2

3

High-throughput

0.628

High

485669

RU2A
U2 small nuclear ribonucleoprotein A'

2

1

High-throughput

0.628

High

1088691

SF3A3
Splicing factor 3A subunit 3

2

1

High-throughput

0.628

High

1105325

SF3B2
Splicing factor 3B subunit 2

2

1

High-throughput

0.628

High

1148514

SF3B4
Splicing factor 3B subunit 4

2

1

High-throughput

0.628

High

1149106

SF3A1
Splicing factor 3A subunit 1

2

1

High-throughput

0.628

High

1274047

NADAP
Kanadaptin

2

1

High-throughput

0.628

High

1274063

SRPK3
SRSF protein kinase 3

2

3

High-throughput

0.628

High

1274039

CCD97
Coiled-coil domain-containing protein 97

2

0

High-throughput

0.602

High

1274049

SKI8
Superkiller complex protein 8

2

0

High-throughput

0.602

High

1155495

EZH2
Histone-lysine N-methyltransferase EZH2

2

1

High-throughput

0.601

High

1050806

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

0

High-throughput

0.547

High

1274044

FOXB1
Forkhead box protein B1

1

1

High-throughput

0.541

High

175716

SR140
U2 snRNP-associated SURP motif-containing protein

1

1

High-throughput

0.536

High

574341

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

High-throughput

0.536

High

890344

NU153
Nuclear pore complex protein Nup153

1

1

High-throughput

0.536

High

974152

RUXG
Small nuclear ribonucleoprotein G

1

3

High-throughput

0.536

High

974591

SMD2
Small nuclear ribonucleoprotein Sm D2

1

1

High-throughput

0.536

High

1006498

SRPK2
SRSF protein kinase 2

1

3

High-throughput

0.536

High

1126971

RBM39
RNA-binding protein 39

1

1

High-throughput

0.536

High

1158755

U1SBP
U11/U12 small nuclear ribonucleoprotein 35 kDa protein

1

1

High-throughput

0.536

High

1274025

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

3

High-throughput

0.536

High

1274026

SUGP1
SURP and G-patch domain-containing protein 1

1

1

High-throughput

0.536

High

1274034

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

1

1

High-throughput

0.536

High

1274040

RNPC3
RNA-binding region-containing protein 3

1

3

High-throughput

0.536

High

1274041

SRPK1
SRSF protein kinase 1

1

3

High-throughput

0.536

High

1274065

RBM7
RNA-binding protein 7

1

2

High-throughput

0.536

High

1274055

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

High-throughput

0.530

High

171082

VP26C
Vacuolar protein sorting-associated protein 26C

1

0

High-throughput

0.513

High

225306

HTSF1
17S U2 SnRNP complex component HTATSF1

1

0

High-throughput

0.513

High

270825

ROCK2
Rho-associated protein kinase 2

1

0

High-throughput

0.513

High

471108

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.513

High

593851

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

0

High-throughput

0.513

High

682534

S100P
Protein S100-P

1

0

High-throughput

0.513

High

876914

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.513

High

944890

PCBP4
Poly(rC)-binding protein 4

1

0

High-throughput

0.513

High

1152334

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

1

0

High-throughput

0.513

High

1160182

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

1234213

SNR48
U11/U12 small nuclear ribonucleoprotein 48 kDa protein

1

0

High-throughput

0.513

High

1274019

COMD6
COMM domain-containing protein 6

1

0

High-throughput

0.513

High

1274021

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.513

High

1274023

DDX42
ATP-dependent RNA helicase DDX42

1

0

High-throughput

0.513

High

1274030

PDCD7
Programmed cell death protein 7

1

0

High-throughput

0.513

High

1274035

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.513

High

1274037

ATRIP
ATR-interacting protein

1

0

High-throughput

0.513

High

1274045

SNR25
U11/U12 small nuclear ribonucleoprotein 25 kDa protein

1

0

High-throughput

0.513

High

1274058

ZMAT5
Zinc finger matrin-type protein 5

1

0

High-throughput

0.513

High

685625

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

Small-scale

0.501

High

1137365

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.493

High

1274020

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

1274036

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

High-throughput

0.486

High

321580

PRP6
Pre-mRNA-processing factor 6

1

1

High-throughput

0.481

High

964345

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

175900

SET1A
Histone-lysine N-methyltransferase SETD1A

1

1

High-throughput

0.479

High

349139

LATS1
Serine/threonine-protein kinase LATS1

1

1

High-throughput

0.479

High

372406

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

406322

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

472848

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.479

High

765656

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.479

High

937801

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.479

High

1149437

SKI2
Superkiller complex protein 2

1

1

High-throughput

0.479

High

1244347

SKI3
Superkiller complex protein 3

1

1

High-throughput

0.479

High

1274033

SNIP1
Smad nuclear-interacting protein 1

1

1

High-throughput

0.479

High

1274038

KAT6A
Histone acetyltransferase KAT6A

1

1

High-throughput

0.479

High

1274043

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.479

High

1274052

SP110
Sp110 nuclear body protein

1

1

High-throughput

0.479

High

1274059

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1274060

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

109437

G5E9A7
DM1 locus, WD repeat containing

1

1

High-throughput

0.470

High

1274057

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.460

High

170211

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

247976

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

257475

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

260119

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

319868

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

324955

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

335869

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.458

High

401044

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

404160

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

606877

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

879223

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

888156

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

941003

HDAC4
Histone deacetylase 4

1

0

High-throughput

0.458

High

970703

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

979889

H4
Histone H4

1

0

High-throughput

0.458

High

998478

H31
Histone H3.1

1

0

High-throughput

0.458

High

1026443

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1106977

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1128762

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

1132782

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

Small-scale

0.458

High

1235453

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.458

High

1240645

CDC73
Parafibromin

1

0

High-throughput

0.458

High

1274022

TAXB1
Tax1-binding protein 1

1

0

High-throughput

0.458

High

1274027

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1274028

YAF2
YY1-associated factor 2

1

0

High-throughput

0.458

High

1274029

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.458

High

1274042

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.458

High

1274048

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.458

High

1274053

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.458

High

1274054

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1274056

AATF
Protein AATF

1

0

High-throughput

0.458

High

1274062

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

47008

PNT87
Transcriptional regulator PINT87aa

1

0

Small-scale

0.426

High

344230

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

1119183

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1203175

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.426

High

1274061

AGO1
Protein argonaute-1

1

0

High-throughput

0.426

High

1244701

TTC33
Tetratricopeptide repeat protein 33

2

0

High-throughput

0.328

High

1274024

ZDH17
Palmitoyltransferase ZDHHC17

1

0

High-throughput

0.282

High

279182

ULK1
Serine/threonine-protein kinase ULK1

1

0

High-throughput

0.279

Low

1136248

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.279

Low

1226694

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

0

High-throughput

0.279

Low

1273203

CHSTF
Carbohydrate sulfotransferase 15

1

0

High-throughput

0.279

Low

1274018

VP35L
VPS35 endosomal protein-sorting factor-like

1

0

High-throughput

0.279

Low

1274031

GPT11
G patch domain-containing protein 11

1

0

High-throughput

0.279

Low

246004

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.268

Low

301515

WFS1
Wolframin

1

0

High-throughput

0.268

Low

954518

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.268

Low

293922

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

375659

RASK
GTPase KRas

1

0

High-throughput

0.249

Low

995665

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.249

Low

1274050

TOLIP
Toll-interacting protein

1

0

High-throughput

0.249

Low

1274051

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

619845

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low

1155071

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

1274032

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025