HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35671810
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 780 Hs			1 1024
+	Hs
		1042791 CUL3_HUMAN (8-780): 0: 754: 22.96		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1041254 CUL1_HUMAN (11-780): 0: 748: 27.84		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1043285 CUL4A_HUMAN (16-780): 0: 744: 24.48		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1043636 CUL4B_HUMAN (16-780): 0: 736: 25.39		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1041493 CUL2_HUMAN (6-780): 0: 699: 26.36		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		808209 CUL5_HUMAN (1-780): 0: 792: 100.00		NEDD4_HUMAN (652-1023): 3.7e-161: 511: 26.04
+	Hs
		983120 CUL4A_HUMAN (16-780): 0: 744: 24.48		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		1042286 CUL3_HUMAN (8-780): 0: 754: 22.96		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		125440 CUL1_HUMAN (11-780): 0: 748: 27.84		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		808117 CUL1_HUMAN (11-780): 0: 748: 27.84		NEDD4_HUMAN (652-1023): 3.7e-161: 511: 26.04