HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	27233966, 28522566
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 522
+	Mm
		936275 CUL5_MOUSE (1-780): 0: 786: 98.46		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Hs
		1020648 CUL3_HUMAN (8-780): 0: 754: 22.96		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1042435 CUL3_HUMAN (8-780): 0: 754: 22.96		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		129560 CUL3_HUMAN (8-780): 0: 754: 22.96		TRAF5_HUMAN (43-500): 4.95e-87: 280: 25.23
+	Hs
		1024672 CUL3_HUMAN (8-780): 0: 754: 22.96		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		536962 CUL5_HUMAN (1-780): 0: 792: 100.00		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1042851 CUL3_HUMAN (8-780): 0: 754: 22.96		PZRN3_HUMAN (55-366): 6.23e-48: 180: 20.31
+	Hs
		1042261 CUL3_HUMAN (8-780): 0: 754: 22.96		TRI11_HUMAN (59-404): 1.13e-49: 179: 12.75
+	Hs
		1041564 CUL3_HUMAN (8-780): 0: 754: 22.96		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		584956 CUL3_HUMAN (8-780): 0: 754: 22.96		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		301806 CUL3_HUMAN (8-780): 0: 754: 22.96		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		1042483 CUL3_HUMAN (8-780): 0: 754: 22.96		TRIM4_HUMAN (61-336): 6.36e-43: 161: 12.90
+	Hs
		536817 CUL3_HUMAN (8-780): 0: 754: 22.96		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1041794 CUL3_HUMAN (8-780): 0: 754: 22.96		TRI68_HUMAN (60-385): 1.41e-42: 160: 12.91
+	Hs
		1019300 CUL3_HUMAN (8-780): 0: 754: 22.96		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59
+	Hs
		1042482 CUL3_HUMAN (8-780): 0: 754: 22.96		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		1042303 CUL3_HUMAN (8-780): 0: 754: 22.96		TRI47_HUMAN (67-316): 1.02e-36: 145: 17.84
+	Hs
		1041848 CUL3_HUMAN (8-780): 0: 754: 22.96		TRAF7_HUMAN (60-208): 5.13e-18: 89.5: 23.26
+	Hs
		1042536 CUL3_HUMAN (8-780): 0: 754: 22.96		RNF41_HUMAN (55-177): 2.33e-17: 84.9: 33.33
+	Hs
		1042230 CUL3_HUMAN (8-780): 0: 754: 22.96		RN166_HUMAN (61-222): 7.37e-16: 79.1: 22.94