Protein: MOT3
Monocarboxylate transporter 3 (MCT 3) (Solute carrier family 16 member 8)

Gene: MOT3, SLC16A8
Organism: Homo sapiens
Interactions: 81
UniProt ID: O95907

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0008028 - monocarboxylic acid transmembrane transporter activity
GO:0015129 - lactate transmembrane transporter activity
GO:0015293 - symporter activity
GO:0015727 - lactate transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

351215

RAB1A
Ras-related protein Rab-1A

1

8

High-throughput

0.494

High

351260

DNJB9
DnaJ homolog subfamily B member 9

1

11

High-throughput

0.494

High

351233

DPP9
Dipeptidyl peptidase 9

1

1

High-throughput

0.489

High

351240

COR2A
Coronin-2A

1

3

High-throughput

0.489

High

136465

GOLI4
Golgi integral membrane protein 4

1

1

High-throughput

0.445

High

321139

ERLN2
Erlin-2

1

9

High-throughput

0.445

High

336520

PIGN
GPI ethanolamine phosphate transferase 1

1

4

High-throughput

0.445

High

351197

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.445

High

351202

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

10

High-throughput

0.445

High

351203

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

7

High-throughput

0.445

High

351204

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

10

High-throughput

0.445

High

351205

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

1

High-throughput

0.445

High

351206

ABCD3
ATP-binding cassette sub-family D member 3

1

7

High-throughput

0.445

High

351210

PHB1
Prohibitin 1

1

5

High-throughput

0.445

High

351211

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

7

High-throughput

0.445

High

351212

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.445

High

351213

CLCN5
H(+)/Cl(-) exchange transporter 5

1

1

High-throughput

0.445

High

351217

AT2C1
Calcium-transporting ATPase type 2C member 1

1

11

High-throughput

0.445

High

351218

ITPR2
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2

1

3

High-throughput

0.445

High

351219

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

3

High-throughput

0.445

High

351220

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

3

High-throughput

0.445

High

351222

TRAM1
Translocating chain-associated membrane protein 1

1

2

High-throughput

0.445

High

351223

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.445

High

351226

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

4

High-throughput

0.445

High

351230

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

2

High-throughput

0.445

High

351238

PIGO
GPI ethanolamine phosphate transferase 3, catalytic subunit

1

4

High-throughput

0.445

High

351239

GPI8
GPI-anchor transamidase

1

2

High-throughput

0.445

High

351243

CERS2
Ceramide synthase 2

1

2

High-throughput

0.445

High

351245

SEC62
Translocation protein SEC62

1

1

High-throughput

0.445

High

351248

DERL1
Derlin-1

1

1

High-throughput

0.445

High

351249

PTSS2
Phosphatidylserine synthase 2

1

1

High-throughput

0.445

High

351252

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.445

High

351253

HEAT1
HEAT repeat-containing protein 1

1

1

High-throughput

0.445

High

351254

AT133
Polyamine-transporting ATPase 13A3

1

15

High-throughput

0.445

High

351256

AT131
Endoplasmic reticulum transmembrane helix translocase

1

10

High-throughput

0.445

High

351257

JPH1
Junctophilin-1

1

1

High-throughput

0.445

High

351259

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

3

High-throughput

0.445

High

351262

STML2
Stomatin-like protein 2, mitochondrial

1

8

High-throughput

0.445

High

351264

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

7

High-throughput

0.445

High

321995

ENDD1
Endonuclease domain-containing 1 protein

1

0

High-throughput

0.426

High

351207

ITPI2
Protein ITPRID2

1

0

High-throughput

0.426

High

351227

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

1

0

High-throughput

0.426

High

351229

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.426

High

351235

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.426

High

351241

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.426

High

351246

TMM43
Transmembrane protein 43

1

0

High-throughput

0.426

High

351247

G6PC3
Glucose-6-phosphatase 3

1

0

High-throughput

0.426

High

193660

TPSN
Tapasin

1

2

High-throughput

0.407

High

258219

TRI13
E3 ubiquitin-protein ligase TRIM13

1

4

High-throughput

0.407

High

283170

ERLN1
Erlin-1

1

4

High-throughput

0.407

High

298646

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

2

High-throughput

0.407

High

301289

WFS1
Wolframin

1

1

High-throughput

0.407

High

351196

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

3

High-throughput

0.407

High

351201

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

2

High-throughput

0.407

High

351209

GLPK
Glycerol kinase

1

1

High-throughput

0.407

High

351214

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

1

High-throughput

0.407

High

351221

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.407

High

351234

MACOI
Macoilin

1

2

High-throughput

0.407

High

351236

MCU
Calcium uniporter protein, mitochondrial

1

3

High-throughput

0.407

High

351237

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.407

High

351250

TMED9
Transmembrane emp24 domain-containing protein 9

1

1

High-throughput

0.407

High

351255

CERS4
Ceramide synthase 4

1

2

High-throughput

0.407

High

351258

DJC11
DnaJ homolog subfamily C member 11

1

9

High-throughput

0.407

High

351263

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

4

High-throughput

0.407

High

351265

TMED5
Transmembrane emp24 domain-containing protein 5

1

2

High-throughput

0.407

High

351216

NTH
Endonuclease III-like protein 1

1

0

High-throughput

0.279

Low

67059

CO061
Uncharacterized protein C15orf61

1

0

High-throughput

0.232

Low

351195

ATP6
ATP synthase F(0) complex subunit a

1

0

High-throughput

0.232

Low

351198

AT5G1
ATP synthase F(0) complex subunit C1, mitochondrial

1

0

High-throughput

0.232

Low

351199

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.232

Low

351200

CX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial

1

0

High-throughput

0.232

Low

351208

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

0

High-throughput

0.232

Low

351224

MBRL
Membralin

1

0

High-throughput

0.232

Low

351225

AG10A
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

1

0

High-throughput

0.232

Low

351228

PGAP1
GPI inositol-deacylase

1

0

High-throughput

0.232

Low

351231

LYCHS
Lysosomal cholesterol signaling protein

1

0

High-throughput

0.232

Low

351232

CF120
UPF0669 protein C6orf120

1

0

High-throughput

0.232

Low

351242

CC127
Coiled-coil domain-containing protein 127

1

0

High-throughput

0.232

Low

351244

GUCD1
Protein GUCD1

1

0

High-throughput

0.232

Low

351251

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

0

High-throughput

0.232

Low

351261

FA8A1
Protein FAM8A1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025