HitPredict

Interactor 1: VPP1 (Q93050)
V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)
Gene: ATP6V0A1

Interactor 2: VPP2 (Q9Y487)
V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)
Gene: ATP6V0A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

The method score is based on:

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	V_ATPase_I~V_ATPase_I
Common GO terms	GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain GO:0005765 - lysosomal membrane GO:0005886 - plasma membrane GO:0007035 - vacuolar acidification GO:0010008 - endosome membrane and 9 others more... GO:0016241 - regulation of macroautophagy GO:0016471 - vacuolar proton-transporting V-type ATPase complex GO:0030670 - phagocytic vesicle membrane GO:0033176 - proton-transporting V-type ATPase complex GO:0043231 - intracellular membrane-bounded organelle GO:0046961 - proton-transporting ATPase activity, rotational mechanism GO:0048471 - perinuclear region of cytoplasm GO:0051117 - ATPase binding GO:1902600 - proton transmembrane transport
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	837
Hs

1	856

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Last updated: 15 Jul 2024