HitPredict

Interactor 1: H2B1H (Q93079)
Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j)
Gene: H2BC9

Interactor 2: NSD1 (Q96L73)
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)
Gene: NSD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	30021884
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~PWWP, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 2696
+	Hs
		1087342 H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41		NSD1_HUMAN (1-2696): 0: 3408: 100.00
+	Hs
		918612 H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21		NSD1_HUMAN (1-2696): 0: 3408: 100.00
+	Hs
		203602 H2B1K_HUMAN (1-126): 1.18e-54: 168: 98.41		SUV91_HUMAN (1705-2081): 6.86e-87: 293: 21.86
+	Hs
		331825 H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41		NSD2_HUMAN (162-430): 3.61e-72: 270: 24.63
+	Hs
		331768 H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21		NSD2_HUMAN (162-430): 3.61e-72: 270: 24.63
+	Hs
		1087410 H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41		EHMT1_HUMAN (1781-2098): 2.45e-65: 247: 20.29
+	Hs
		918699 H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21		EHMT1_HUMAN (1781-2098): 2.45e-65: 247: 20.29
+	Hs
		1087341 H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41		EHMT2_HUMAN (1826-2080): 8.77e-63: 239: 22.49
+	Hs
		1274453 H2B1H_HUMAN (1-126): 4.31e-55: 169: 100.00		ASH1L_HUMAN (1243-2111): 4.6e-62: 239: 17.33
+	Hs
		918611 H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21		EHMT2_HUMAN (1826-2080): 8.77e-63: 239: 22.49
+	Hs
		1087385 H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41		NSD3_HUMAN (130-430): 6.42e-60: 231: 24.92
+	Hs
		707738 H2B1B_HUMAN (1-126): 1.44e-54: 168: 96.83		NSD3_HUMAN (130-430): 6.42e-60: 231: 24.92
+	Hs
		918663 H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21		NSD3_HUMAN (130-430): 6.42e-60: 231: 24.92
+	Hs
		1079994 H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		1080205 H2B1H_HUMAN (1-126): 4.31e-55: 169: 100.00		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		241535 H2B1K_HUMAN (1-126): 1.18e-54: 168: 98.41		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		918389 H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		707690 H2B1B_HUMAN (1-126): 1.44e-54: 168: 96.83		KMT2C_HUMAN (2086-2261): 7.67e-10: 67.3: 13.44
+	Hs
		918533 H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21		KMT2C_HUMAN (2086-2261): 7.67e-10: 67.3: 13.44
+	Hs
		152598 H2B1B_HUMAN (1-126): 1.44e-54: 168: 96.83		KMT2D_HUMAN (1011-1538): 2.41e-09: 65.8: 8.69