Protein: HERC2
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)

Gene: HERC2
Organism: Mus musculus
Interactions: 69
UniProt ID: Q4U2R1

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005743 - mitochondrial inner membrane
GO:0005814 - centriole
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1196095

ANK2
Ankyrin-2

1

8

High-throughput

0.691

High

509071

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

1

20

High-throughput

0.647

High

148242

UBE3A
Ubiquitin-protein ligase E3A

1

17

High-throughput

0.575

High

1196092

Q80W01
AU042671 protein

1

17

High-throughput

0.553

High

59390

MA7D1
MAP7 domain-containing protein 1

1

14

High-throughput

0.536

High

59683

UBR4
E3 ubiquitin-protein ligase UBR4

1

3

High-throughput

0.536

High

98290

E9QAP7
TATA-box binding protein associated factor 4

1

7

High-throughput

0.536

High

147506

DPYL2
Dihydropyrimidinase-related protein 2

1

10

High-throughput

0.536

High

518677

EF1A1
Elongation factor 1-alpha 1

1

5

High-throughput

0.536

High

670052

MCM3
DNA replication licensing factor MCM3

1

7

High-throughput

0.536

High

704814

KIF5C
Kinesin heavy chain isoform 5C

1

9

High-throughput

0.536

High

921210

CUX1
Homeobox protein cut-like 1

1

9

High-throughput

0.536

High

968096

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

4

High-throughput

0.536

High

989964

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

1000004

HDAC2
Histone deacetylase 2

1

8

High-throughput

0.536

High

1000354

TP53B
TP53-binding protein 1

1

10

High-throughput

0.536

High

1013578

TNIK
Traf2 and NCK-interacting protein kinase

1

20

High-throughput

0.536

High

1030278

SC23A
Protein transport protein Sec23A

1

5

High-throughput

0.536

High

1196070

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.536

High

1196071

NEUL4
Neuralized-like protein 4

1

1

High-throughput

0.536

High

1196074

FXR1
RNA-binding protein FXR1

1

12

High-throughput

0.536

High

1196075

KINH
Kinesin-1 heavy chain

1

10

High-throughput

0.536

High

1196076

RAI1
Retinoic acid-induced protein 1

1

7

High-throughput

0.536

High

1196077

MYH10
Myosin-10

1

1

High-throughput

0.536

High

1196078

DDX3X
ATP-dependent RNA helicase DDX3X

1

9

High-throughput

0.536

High

1196079

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

9

High-throughput

0.536

High

1196080

SRBS1
Sorbin and SH3 domain-containing protein 1

1

10

High-throughput

0.536

High

1196081

CE170
Centrosomal protein of 170 kDa

1

6

High-throughput

0.536

High

1196083

HDAC4
Histone deacetylase 4

1

9

High-throughput

0.536

High

1196084

KIF15
Kinesin-like protein KIF15

1

9

High-throughput

0.536

High

1196085

KIF11
Kinesin-like protein KIF11

1

10

High-throughput

0.536

High

1196086

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

High-throughput

0.536

High

1196089

AKAP9
A-kinase anchor protein 9

1

12

High-throughput

0.536

High

1196090

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

16

High-throughput

0.536

High

1196094

TREF1
Transcriptional-regulating factor 1

1

5

High-throughput

0.536

High

1196097

MATR3
Matrin-3

1

11

High-throughput

0.536

High

1196099

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

11

High-throughput

0.536

High

1196100

DYST
Dystonin

1

10

High-throughput

0.536

High

1196103

RENT1
Regulator of nonsense transcripts 1

1

5

High-throughput

0.536

High

1196105

FLII
Protein flightless-1 homolog

1

7

High-throughput

0.536

High

1196106

Q9JMG9
BTB/POZ domain zinc finger transcription factor

1

2

High-throughput

0.536

High

1196107

DREB
Drebrin

1

14

High-throughput

0.536

High

1196110

CARM1
Histone-arginine methyltransferase CARM1

1

6

High-throughput

0.536

High

1196087

Q6ZQ86
MKIAA0614 protein

1

17

High-throughput

0.514

High

948494

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.513

High

1196088

SYNE2
Nesprin-2

1

9

High-throughput

0.489

High

1196091

MAP6
Microtubule-associated protein 6

1

9

High-throughput

0.489

High

1196096

SHOT1
Shootin-1

1

2

High-throughput

0.489

High

1196109

COR1C
Coronin-1C

1

7

High-throughput

0.489

High

74695

B2RXW8
Ppfia1 protein

1

2

High-throughput

0.479

High

98269

E9QAE4
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

7

High-throughput

0.479

High

382478

P53
Cellular tumor antigen p53

1

18

Small-scale

0.479

High

845182

EAA2
Excitatory amino acid transporter 2

1

7

Small-scale

0.479

High

1196072

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

Small-scale

0.479

High

1196073

SC6A4
Sodium-dependent serotonin transporter

1

4

High-throughput

0.479

High

1196093

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

12

High-throughput

0.479

High

1196101

EED
Polycomb protein EED

1

10

High-throughput

0.479

High

1196102

Q99LH8
Tacc3 protein

1

4

High-throughput

0.479

High

74659

B2RXQ2
Ppfia1 protein

1

4

High-throughput

0.445

High

312390

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

8

High-throughput

0.445

High

777882

FMR1
Fragile X messenger ribonucleoprotein 1

1

12

High-throughput

0.445

High

854786

SIPA1
Signal-induced proliferation-associated protein 1

1

4

High-throughput

0.445

High

1196104

TACC3
Transforming acidic coiled-coil-containing protein 3

1

5

High-throughput

0.445

High

1196108

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4

1

10

High-throughput

0.445

High

59185

A2A9M5
Dedicator of cytokinesis 7

1

1

High-throughput

0.437

High

108290

G3X928
SEC23-interacting protein

1

6

High-throughput

0.437

High

1191347

Q3V403
Signal-induced proliferation-associated protein 1

1

4

High-throughput

0.437

High

1196082

S23IP
SEC23-interacting protein

1

6

High-throughput

0.407

High

1196098

DOCK7
Dedicator of cytokinesis protein 7

1

1

High-throughput

0.407

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025