HitPredict

Interactor 1: HDAC1 (Q94517)
Histone deacetylase HDAC1 (HD) (EC 3.5.1.98)
Gene: HDAC1

Interactor 2: Q9W410 (Q9W410)
GH06635p
Gene: PF1

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	19114561, 19782028
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0070822 - Sin3-type complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 521 Dm			1 878
+	Hs
		1270388 HDAC2_HUMAN (2-488): 0: 659: 76.59		PHF12_HUMAN (3-382): 9.98e-68: 246: 33.33
+	Hs
		170436 HDAC2_HUMAN (2-488): 0: 659: 76.59		TIF1A_HUMAN (4-210): 6.38e-33: 139: 19.62
+	Dm
		1276536 HDAC1_DROME (1-521): 0: 674: 100.00		Q9VDK5_DROME (5-199): 6.2e-26: 117: 19.39
+	Dm
		68996 HDAC1_DROME (1-521): 0: 674: 100.00		A8WHL4_DROME (5-199): 6.49e-26: 117: 19.39
+	Dm
		1276545 HDAC1_DROME (1-521): 0: 674: 100.00		KDM5_DROME (36-110): 3.48e-17: 89.2: 29.49
+	Hs
		217495 HDAC2_HUMAN (2-488): 0: 659: 76.59		AIRE_HUMAN (52-132): 2.43e-20: 98: 39.76
+	Hs
		782369 HDAC2_HUMAN (2-488): 0: 659: 76.59		KDM5C_HUMAN (4-112): 9.86e-20: 97.4: 25.00
+	Hs
		1270501 HDAC2_HUMAN (2-488): 0: 659: 76.59		KDM5B_HUMAN (3-112): 3.13e-19: 95.8: 22.31
+	Dm
		332806 HDAC1_DROME (1-521): 0: 674: 100.00		CHDM_DROME (102-448): 1.23e-14: 80.8: 12.70
+	Hs
		1018617 HDAC2_HUMAN (2-488): 0: 659: 76.59		CHD3_HUMAN (5-251): 4.45e-18: 92: 14.24
+	Hs
		1255037 HDAC2_HUMAN (2-488): 0: 659: 76.59		CHD5_HUMAN (49-250): 1.03e-17: 90.8: 16.80
+	Hs
		666546 HDAC2_HUMAN (2-488): 0: 659: 76.59		KDM5A_HUMAN (36-112): 4.81e-17: 88.5: 28.75
+	Hs
		1270364 HDAC2_HUMAN (2-488): 0: 659: 76.59		PF21A_HUMAN (101-313): 4.06e-17: 88: 17.49
+	Hs
		1059770 HDAC2_HUMAN (2-488): 0: 659: 76.59		CHD4_HUMAN (249-345): 2.41e-16: 86.6: 23.71
+	Hs
		1017332 HDAC2_HUMAN (2-488): 0: 659: 76.59		BPTF_HUMAN (36-104): 5.78e-16: 85.3: 34.78
+	Mm
		936393 HDAC2_MOUSE (2-488): 0: 655: 76.18		Q5DTP7_MOUSE (249-345): 1.02e-16: 87.7: 24.74
+	Mm
		56900 HDAC2_MOUSE (2-488): 0: 655: 76.18		CHD5_MOUSE (148-303): 2.14e-13: 76.9: 17.95
+	Hs
		331858 HDAC2_HUMAN (2-488): 0: 659: 76.59		NSD2_HUMAN (40-356): 5.01e-12: 72.3: 14.86
+	Hs
		299073 HDAC2_HUMAN (2-488): 0: 659: 76.59		PHF14_HUMAN (17-122): 2.27e-09: 63.3: 20.00
+	Mm
		56897 HDAC1_MOUSE (3-443): 0: 640: 81.18		CHD5_MOUSE (148-303): 2.14e-13: 76.9: 17.95