HitPredict

Interactor 1: CUL1 (Q94AH6)
Cullin-1
Gene: CUL1

Interactor 2: EBF1 (Q9SKK0)
EIN3-binding F-box protein 1 (F-box/LRR-repeat protein 6)
Gene: EBF1

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.864

Property	Details
Experiments	32612234, 14675533, unassigned2354
Identification Methods	two hybrid, pull down, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process GO:0009873 - ethylene-activated signaling pathway GO:0016567 - protein ubiquitination and 1 others more... GO:0019005 - SCF ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 738 At			1 628
+	At
		221522 CUL1_ARATH (1-738): 0: 837: 100.00		SKP2B_ARATH (337-619): 1.08e-28: 119: 18.97
+	Hs
		1042760 CUL3_HUMAN (1-738): 0: 796: 30.09		FXL17_HUMAN (269-627): 4.96e-35: 142: 17.18
+	At
		1277335 CUL1_ARATH (1-738): 0: 837: 100.00		AFB3_ARATH (232-628): 8.65e-21: 98.7: 16.71
+	At
		1277334 CUL1_ARATH (1-738): 0: 837: 100.00		SKP2A_ARATH (469-627): 8.81e-20: 93.3: 29.88
+	At
		1123013 CUL1_ARATH (1-738): 0: 837: 100.00		TIR1_ARATH (206-627): 5.64e-18: 89.8: 14.82
+	At
		1277350 CUL1_ARATH (1-738): 0: 837: 100.00		GRH1_ARATH (381-627): 5.47e-12: 70.5: 17.98
+	At
		1173680 CUL1_ARATH (1-738): 0: 837: 100.00		EBF2_ARATH (430-628): 8.01e-11: 67.1: 21.40
+	At
		137942 CUL1_ARATH (1-738): 0: 837: 100.00		COI1_ARATH (353-627): 1.67e-10: 66: 13.67
+	Hs
		1041088 CUL1_HUMAN (4-738): 0: 729: 30.41		FXL14_HUMAN (383-628): 2.27e-37: 145: 22.35
+	Hs
		1041248 CUL1_HUMAN (4-738): 0: 729: 30.41		FXL17_HUMAN (269-627): 4.96e-35: 142: 17.18
+	Hs
		1043217 CUL4A_HUMAN (13-738): 0: 788: 34.61		FXL15_HUMAN (459-627): 2.62e-14: 76: 19.67
+	Hs
		1041267 CUL1_HUMAN (4-738): 0: 729: 30.41		FBXL2_HUMAN (394-627): 5.61e-29: 121: 23.53
+	Hs
		1041256 CUL1_HUMAN (4-738): 0: 729: 30.41		FBXL7_HUMAN (124-334): 2.36e-27: 117: 27.01
+	Dm
		1097202 CUL1_DROME (3-738): 0: 692: 27.81		Q9VF10_DROME (372-627): 9.91e-30: 127: 21.97
+	Hs
		1041146 CUL1_HUMAN (4-738): 0: 729: 30.41		FXL20_HUMAN (460-627): 4.1e-16: 82.9: 21.77
+	Mm
		1321914 CUL1_MOUSE (4-738): 0: 729: 30.41		FXL20_MOUSE (460-627): 7.4e-16: 82.1: 21.77
+	Hs
		1041495 CUL2_HUMAN (1-738): 0: 688: 27.05		FBXL2_HUMAN (394-627): 5.61e-29: 121: 23.53
+	Hs
		1041197 CUL1_HUMAN (4-738): 0: 729: 30.41		FXL15_HUMAN (459-627): 2.62e-14: 76: 19.67
+	Hs
		1041265 CUL1_HUMAN (4-738): 0: 729: 30.41		FBXL4_HUMAN (172-279): 1.02e-09: 63.5: 32.73
+	Sc
		624323 CDC53_YEAST (3-738): 0: 601: 21.87		GRR1_YEAST (110-256): 5.7e-10: 64.8: 16.00