HitPredict

Interactor 1: CSN6 (Q95PZ0)
COP9 signalosome complex subunit 6 (Signalosome subunit 6)
Gene: csn-6

Interactor 2: CSN4 (Q9N359)
COP9 signalosome complex subunit 4 (Signalosome subunit 4)
Gene: csn-4

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.829

Property	Details
Experiments	18692475, 12781129, unassigned701
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	JAB~PCI, MitMem_reg~PCI
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008180 - COP9 signalosome GO:0048477 - oogenesis GO:0060184 - cell cycle switching and 1 others more... GO:1905879 - regulation of oogenesis
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 426 Ce			1 412
+	Ce
		86683 C5VUK2_CAEEL (1-426): 5.63e-174: 495: 98.61		CSN4_CAEEL (1-412): 3.64e-149: 430: 100.00
+	Mm
		291852 CSN6_MOUSE (9-298): 6.46e-95: 289: 28.81		CSN4_MOUSE (7-407): 5.75e-142: 412: 35.57
+	Hs
		1184960 CSN6_HUMAN (9-298): 1.45e-94: 289: 29.15		CSN4_HUMAN (7-407): 1.67e-141: 411: 35.82
+	Dm
		1358198 CSN6_DROME (1-298): 1.57e-89: 276: 31.35		CSN4_DROME (7-411): 4.82e-145: 420: 35.47
+	At
		1226049 CSN6A_ARATH (5-297): 3.6e-89: 274: 23.34		CSN4_ARATH (23-403): 1.18e-117: 350: 33.33
+	Hs
		121968 PSMD7_HUMAN (10-300): 9.77e-91: 279: 20.82		PSD12_HUMAN (57-404): 1.71e-105: 320: 15.73
+	Dm
		640782 PSMD7_DROME (10-343): 9.66e-96: 292: 19.29		Q9V3Z4_DROME (59-404): 1.19e-91: 287: 15.18
+	Sc
		996267 RPN8_YEAST (12-355): 2.34e-83: 260: 20.74		RPN5_YEAST (55-404): 4.19e-91: 283: 18.36
+	Hs
		121895 EIF3H_HUMAN (8-311): 7.67e-66: 215: 12.50		PSD12_HUMAN (57-404): 1.71e-105: 320: 15.73
+	At
		1226054 EIF3H_ARATH (1-294): 2.59e-52: 180: 12.26		CSN4_ARATH (23-403): 1.18e-117: 350: 33.33