HitPredict

Interactor 1: IGSF8 (Q969P0)
Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316)
Gene: IGSF8

Interactor 2: TMX4 (Q9H1E5)
Thioredoxin-related transmembrane protein 4 (Thioredoxin domain-containing protein 13)
Gene: TMX4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Thioredoxin~V-set
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 613 Hs			1 349
+	Hs
		1281786 IGSF8_HUMAN (1-613): 5.61e-173: 507: 100.00		TMX1_HUMAN (37-241): 1.77e-64: 207: 43.42
+	Hs
		1067783 IGSF8_HUMAN (1-613): 5.61e-173: 507: 100.00		PDIA6_HUMAN (3-156): 4.69e-36: 137: 18.71
+	Hs
		255928 OBSL1_HUMAN (92-559): 2.57e-11: 69.3: 15.13		TXND5_HUMAN (7-268): 4.56e-58: 195: 19.10
+	Hs
		1077850 MYLK_HUMAN (55-280): 1.58e-10: 66.8: 9.96		TXND5_HUMAN (7-268): 4.56e-58: 195: 19.10
+	Hs
		255801 OBSL1_HUMAN (92-559): 2.57e-11: 69.3: 15.13		PDIA6_HUMAN (3-156): 4.69e-36: 137: 18.71
+	Hs
		1067713 MYLK_HUMAN (55-280): 1.58e-10: 66.8: 9.96		PDIA6_HUMAN (3-156): 4.69e-36: 137: 18.71
+	Hs
		671883 TITIN_HUMAN (169-612): 1.96e-12: 72.9: 9.60		PDIA3_HUMAN (5-143): 3.25e-33: 130: 17.01
+	Hs
		255537 OBSL1_HUMAN (92-559): 2.57e-11: 69.3: 15.13		PDIA3_HUMAN (5-143): 3.25e-33: 130: 17.01
+	Hs
		423239 MYLK_HUMAN (55-280): 1.58e-10: 66.8: 9.96		PDIA1_HUMAN (27-137): 2.54e-31: 125: 17.80
+	Hs
		255474 OBSL1_HUMAN (92-559): 2.57e-11: 69.3: 15.13		PDIA4_HUMAN (127-276): 4.35e-10: 63: 10.26