Protein: ANK2
Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)

Gene: ANK2
Organism: Homo sapiens
Interactions: 206
UniProt ID: Q01484

Gene Ontology (top 5):
GO:0002027 - regulation of heart rate
GO:0003283 - atrial septum development
GO:0005200 - structural constituent of cytoskeleton
GO:0005739 - mitochondrion
GO:0005764 - lysosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1030702

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

3

12

High-throughput

0.861

High

139376

NCHL1
Neural cell adhesion molecule L1-like protein

2

8

High-throughput

0.811

High

1030714

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

3

High-throughput

0.811

High

1030710

TNIK
TRAF2 and NCK-interacting protein kinase

2

10

High-throughput

0.762

High

400671

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

3

High-throughput

0.754

High

764670

CTNB1
Catenin beta-1

2

4

Small-scale

0.754

High

413644

P53
Cellular tumor antigen p53

1

1

High-throughput

0.724

High

177203

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

13

High-throughput

0.698

High

174745

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

20

High-throughput

0.691

High

239309

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

19

High-throughput

0.691

High

374532

RASH
GTPase HRas

1

6

High-throughput

0.691

High

457372

TBB5
Tubulin beta chain

1

2

High-throughput

0.691

High

482604

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

2

High-throughput

0.691

High

577716

PLAK
Junction plakoglobin

1

5

High-throughput

0.691

High

731917

L1CAM
Neural cell adhesion molecule L1

1

8

High-throughput

0.691

High

893482

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

3

High-throughput

0.691

High

920430

DAPK1
Death-associated protein kinase 1

1

15

High-throughput

0.691

High

988289

RAC1
Ras-related C3 botulinum toxin substrate 1

1

4

High-throughput

0.691

High

1028731

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

20

High-throughput

0.691

High

1030637

LSAMP
Limbic system-associated membrane protein

1

2

High-throughput

0.691

High

1030639

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

19

High-throughput

0.691

High

1030640

TBB2A
Tubulin beta-2A chain

1

2

High-throughput

0.691

High

1030665

TBA1A
Tubulin alpha-1A chain

1

4

High-throughput

0.691

High

1030712

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

20

High-throughput

0.691

High

1030700

KTU
Protein kintoun

3

1

High-throughput

0.667

High

915065

CAZA1
F-actin-capping protein subunit alpha-1

1

0

High-throughput

0.656

High

952111

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

3

15

Small-scale

0.656

High

596835

EPB42
Protein 4.2

1

1

Small-scale

0.647

High

124311

HAX1
HCLS1-associated protein X-1

3

0

High-throughput

0.638

High

1030650

DGUOK
Deoxyguanosine kinase, mitochondrial

3

0

High-throughput

0.638

High

1030708

NUFP1
FMR1-interacting protein NUFIP1

3

0

High-throughput

0.638

High

1030674

RPGF5
Rap guanine nucleotide exchange factor 5

2

3

High-throughput

0.628

High

1030706

RRBP1
Ribosome-binding protein 1

2

12

High-throughput

0.621

High

85975

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

2

High-throughput

0.618

High

769973

RFC1
Replication factor C subunit 1

1

1

High-throughput

0.618

High

1030698

TANC2
Protein TANC2

1

18

High-throughput

0.618

High

330879

KI20A
Kinesin-like protein KIF20A

1

6

High-throughput

0.618

High

363144

EGFR
Epidermal growth factor receptor

1

11

High-throughput

0.618

High

375418

RASK
GTPase KRas

1

8

High-throughput

0.618

High

463458

LYN
Tyrosine-protein kinase Lyn

1

4

High-throughput

0.618

High

541441

FGFR1
Fibroblast growth factor receptor 1

1

15

High-throughput

0.618

High

547433

DMD
Dystrophin

1

20

Small-scale

0.618

High

593966

NCK1
SH2/SH3 adapter protein NCK1

1

3

High-throughput

0.618

High

710812

EPHB2
Ephrin type-B receptor 2

1

7

High-throughput

0.618

High

830583

CCNF
Cyclin-F

1

4

High-throughput

0.618

High

987550

GRB2
Growth factor receptor-bound protein 2

1

7

High-throughput

0.618

High

989719

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

4

High-throughput

0.618

High

1030644

ZYX
Zyxin

1

6

High-throughput

0.618

High

1030655

OBSCN
Obscurin

1

7

Small-scale

0.618

High

1030663

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.618

High

943916

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

16

High-throughput

0.590

High

1030697

POPD2
Popeye domain-containing protein 2

2

0

High-throughput

0.585

High

1030688

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

2

15

Small-scale

0.585

High

1030685

NDEL1
Nuclear distribution protein nudE-like 1

2

8

High-throughput

0.576

High

712

KV240
Immunoglobulin kappa variable 2-40

1

1

High-throughput

0.575

High

254974

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.575

High

378781

LV208
Immunoglobulin lambda variable 2-8

1

1

High-throughput

0.575

High

379348

IGHG2
Immunoglobulin heavy constant gamma 2

1

4

High-throughput

0.575

High

934478

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.575

High

1030653

GNAS1
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

1

4

High-throughput

0.575

High

1030642

KCJ11
ATP-sensitive inward rectifier potassium channel 11

1

2

Small-scale

0.569

High

1030692

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

18

High-throughput

0.555

High

529650

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.554

High

979515

H4
Histone H4

1

1

High-throughput

0.553

High

1030715

PLAK2
PALM2-AKAP2 fusion protein

2

3

High-throughput

0.552

High

327951

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

15

Small-scale

0.550

High

1030691

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

15

Small-scale

0.550

High

298901

DNJB5
DnaJ homolog subfamily B member 5

1

3

High-throughput

0.541

High

1030646

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.537

High

225476

CYH3
Cytohesin-3

1

3

High-throughput

0.536

High

227851

MYO1B
Unconventional myosin-Ib

1

8

High-throughput

0.536

High

250556

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

6

High-throughput

0.536

High

281308

GGYF1
GRB10-interacting GYF protein 1

1

7

High-throughput

0.536

High

318308

MYO1D
Unconventional myosin-Id

1

7

High-throughput

0.536

High

384135

CO1A1
Collagen alpha-1(I) chain

1

2

High-throughput

0.536

High

445825

ENOA
Alpha-enolase

1

4

High-throughput

0.536

High

446917

NPM
Nucleophosmin

1

1

High-throughput

0.536

High

451144

NFL
Neurofilament light polypeptide

1

15

High-throughput

0.536

High

451367

NFM
Neurofilament medium polypeptide

1

15

High-throughput

0.536

High

468274

HS90B
Heat shock protein HSP 90-beta

1

7

High-throughput

0.536

High

474621

VIME
Vimentin

1

15

High-throughput

0.536

High

534946

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.536

High

536991

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.536

High

583076

VATB1
V-type proton ATPase subunit B, kidney isoform

1

1

High-throughput

0.536

High

620303

NUCL
Nucleolin

1

2

High-throughput

0.536

High

629793

BTF3
Transcription factor BTF3

1

1

High-throughput

0.536

High

639120

SYT1
Synaptotagmin-1

1

1

High-throughput

0.536

High

684489

CTNA2
Catenin alpha-2

1

2

High-throughput

0.536

High

690915

1433T
14-3-3 protein theta

1

14

High-throughput

0.536

High

715228

RABP1
Cellular retinoic acid-binding protein 1

1

2

High-throughput

0.536

High

772749

MYH9
Myosin-9

1

4

High-throughput

0.536

High

773158

MYH10
Myosin-10

1

3

High-throughput

0.536

High

774057

ADDA
Alpha-adducin

1

3

High-throughput

0.536

High

777444

K22E
Keratin, type II cytoskeletal 2 epidermal

1

11

High-throughput

0.536

High

833250

PERI
Peripherin

1

15

High-throughput

0.536

High

852725

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

1

High-throughput

0.536

High

861124

MAP1B
Microtubule-associated protein 1B

1

9

High-throughput

0.536

High

947090

RTP1
Receptor-transporting protein 1

1

1

High-throughput

0.536

High

952752

ACTB
Actin, cytoplasmic 1

1

6

High-throughput

0.536

High

967671

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.536

High

971417

1433E
14-3-3 protein epsilon

1

2

High-throughput

0.536

High

983454

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

4

High-throughput

0.536

High

986348

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.536

High

990109

1433Z
14-3-3 protein zeta/delta

1

14

High-throughput

0.536

High

993416

ACTH
Actin, gamma-enteric smooth muscle

1

6

High-throughput

0.536

High

1006981

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.536

High

1010286

BASP1
Brain acid soluble protein 1

1

4

High-throughput

0.536

High

1030635

CKAP4
Cytoskeleton-associated protein 4

1

7

High-throughput

0.536

High

1030641

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.536

High

1030645

AINX
Alpha-internexin

1

12

High-throughput

0.536

High

1030648

DREB
Drebrin

1

6

High-throughput

0.536

High

1030652

ACTBL
Beta-actin-like protein 2

1

6

High-throughput

0.536

High

1030657

VIR
Protein virilizer homolog

1

3

High-throughput

0.536

High

1030662

MPRIP
Myosin phosphatase Rho-interacting protein

1

14

High-throughput

0.536

High

1030678

FMNL2
Formin-like protein 2

1

2

High-throughput

0.536

High

1030684

SRCN1
SRC kinase signaling inhibitor 1

1

4

High-throughput

0.536

High

1030690

PABP3
Polyadenylate-binding protein 3

1

2

High-throughput

0.536

High

1030694

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

2

High-throughput

0.536

High

1030696

PKHA5
Pleckstrin homology domain-containing family A member 5

1

12

High-throughput

0.536

High

1030703

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

4

High-throughput

0.536

High

1030716

E41L3
Band 4.1-like protein 3

1

12

High-throughput

0.536

High

1030717

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

10

High-throughput

0.536

High

1030718

MYO5A
Unconventional myosin-Va

1

3

High-throughput

0.536

High

1030719

SNX9
Sorting nexin-9

1

5

High-throughput

0.536

High

105772

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

1030669

RYBP
RING1 and YY1-binding protein

2

2

High-throughput

0.521

High

1030701

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.517

High

123369

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.513

High

369858

CO3
Complement C3

1

0

High-throughput

0.513

High

607296

NEUM
Neuromodulin

1

0

High-throughput

0.513

High

612607

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.513

High

784587

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.513

High

880287

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.513

High

898609

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.513

High

906871

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.513

High

928765

CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

1

0

High-throughput

0.513

High

948056

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

0

High-throughput

0.513

High

961261

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.513

High

985134

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.513

High

996109

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.513

High

1030631

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.513

High

1030632

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.513

High

1030633

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.513

High

1030634

RL18
Large ribosomal subunit protein eL18

1

0

High-throughput

0.513

High

1030649

FSCN1
Fascin

1

0

High-throughput

0.513

High

1030651

RABL6
Rab-like protein 6

1

0

High-throughput

0.513

High

1030658

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.513

High

1030659

CDC73
Parafibromin

1

0

High-throughput

0.513

High

1030666

R4RL2
Reticulon-4 receptor-like 2

1

0

High-throughput

0.513

High

1030671

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.513

High

1030675

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.513

High

1030704

EHD3
EH domain-containing protein 3

1

12

Small-scale

0.506

High

736467

NAC1
Sodium/calcium exchanger 1

1

1

Small-scale

0.501

High

839745

EPS15
Epidermal growth factor receptor substrate 15

1

12

High-throughput

0.501

High

1030682

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

15

Small-scale

0.501

High

1030686

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

15

Small-scale

0.501

High

1030636

ABCC8
ATP-binding cassette sub-family C member 8

1

1

Small-scale

0.500

High

285883

SF3B1
Splicing factor 3B subunit 1

1

1

High-throughput

0.489

High

910465

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

3

High-throughput

0.489

High

1030643

NONO
Non-POU domain-containing octamer-binding protein

1

3

High-throughput

0.489

High

1030668

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

3

High-throughput

0.489

High

1030676

MAP6
Microtubule-associated protein 6

1

12

High-throughput

0.489

High

1030681

PSD2
PH and SEC7 domain-containing protein 2

1

4

High-throughput

0.489

High

1030713

COR2B
Coronin-2B

1

4

High-throughput

0.489

High

1030670

CE120
Centrosomal protein of 120 kDa

1

10

High-throughput

0.488

High

1030656

ECM29
Proteasome adapter and scaffold protein ECM29

1

3

Small-scale

0.481

High

299151

FLOT1
Flotillin-1

1

2

High-throughput

0.479

High

411756

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.479

High

459549

PROF1
Profilin-1

1

3

High-throughput

0.479

High

582749

EZRI
Ezrin

1

10

High-throughput

0.479

High

642806

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

5

High-throughput

0.479

High

679134

DNJB1
DnaJ homolog subfamily B member 1

1

3

High-throughput

0.479

High

715544

MARCS
Myristoylated alanine-rich C-kinase substrate

1

6

High-throughput

0.479

High

959133

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

1008685

RED1
Double-stranded RNA-specific editase 1

1

5

High-throughput

0.479

High

1030647

OCLN
Occludin

1

2

High-throughput

0.479

High

1030667

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1030672

OTU7A
OTU domain-containing protein 7A

1

9

High-throughput

0.479

High

1030689

EHD4
EH domain-containing protein 4

1

12

Small-scale

0.479

High

1030693

EHD1
EH domain-containing protein 1

1

12

Small-scale

0.479

High

1030705

EHD2
EH domain-containing protein 2

1

12

Small-scale

0.479

High

1030707

DNJB4
DnaJ homolog subfamily B member 4

1

3

High-throughput

0.479

High

1030711

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.479

High

355635

MOC2A
Molybdopterin synthase sulfur carrier subunit

1

0

High-throughput

0.458

High

358668

LDHA
L-lactate dehydrogenase A chain

1

0

High-throughput

0.458

High

443051

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.458

High

949001

SC61G
Protein transport protein Sec61 subunit gamma

1

0

High-throughput

0.458

High

1030679

MTEF1
Transcription termination factor 1, mitochondrial

1

0

High-throughput

0.458

High

1030680

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

Small-scale

0.458

High

1030709

DCTN4
Dynactin subunit 4

1

0

Small-scale

0.458

High

1030638

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

3

High-throughput

0.457

High

516164

HS71A
Heat shock 70 kDa protein 1A

1

6

High-throughput

0.445

High

1030677

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

3

High-throughput

0.445

High

855429

ATRX
Transcriptional regulator ATRX

1

3

High-throughput

0.437

High

998221

H31
Histone H3.1

1

2

High-throughput

0.437

High

1030664

H32
Histone H3.2

1

2

High-throughput

0.437

High

1030673

BBX
HMG box transcription factor BBX

1

2

High-throughput

0.437

High

404768

PRIO
Major prion protein

1

0

High-throughput

0.426

High

1030695

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1030654

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.279

Low

1030660

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.279

Low

1030661

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.279

Low

1030683

CRNL1
Crooked neck-like protein 1

1

0

High-throughput

0.279

Low

1030687

CHST5
Carbohydrate sulfotransferase 5

1

0

High-throughput

0.279

Low

1030699

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

0

High-throughput

0.279

Low

596048

H12
Histone H1.2

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025