HitPredict

Interactor 1: ISL2 (Q96A47)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Interactor 2: SSBP3 (Q9BWW4)
Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein)
Gene: SSBP3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	26186194, 28514442, 30833792, 24981860, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Hs			1 388
+	Hs
		899933 ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91		SSBP3_HUMAN (1-388): 5.14e-67: 218: 100.00
+	Mm
		899944 ISL1_MOUSE (14-358): 6.97e-87: 268: 73.91		SSBP3_MOUSE (1-388): 5.14e-67: 218: 100.00
+	Mm
		1321868 ISL2_MOUSE (1-359): 3.88e-85: 263: 98.61		SSBP3_MOUSE (1-388): 5.14e-67: 218: 100.00
+	Hs
		899932 ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91		SSBP4_HUMAN (5-388): 9.47e-57: 192: 69.25
+	Hs
		1283495 ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00		SSBP4_HUMAN (5-388): 9.47e-57: 192: 69.25
+	Mm
		1112383 ISL2_MOUSE (1-359): 3.88e-85: 263: 98.61		Q3U4B1_MOUSE (1-388): 1.81e-48: 169: 62.66
+	Mm
		899943 ISL1_MOUSE (14-358): 6.97e-87: 268: 73.91		SSBP2_MOUSE (3-388): 9.79e-45: 159: 77.00
+	Hs
		899917 ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91		SSBP2_HUMAN (3-388): 2.7e-44: 158: 77.26
+	Mm
		1321867 ISL2_MOUSE (1-359): 3.88e-85: 263: 98.61		SSBP2_MOUSE (3-388): 9.79e-45: 159: 77.00
+	Hs
		946656 ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00		SSBP2_HUMAN (3-388): 2.7e-44: 158: 77.26
+	Mm
		1321929 LHX2_MOUSE (24-326): 2.86e-58: 195: 27.76		SSBP3_MOUSE (1-388): 5.14e-67: 218: 100.00
+	Hs
		839819 LHX2_HUMAN (24-326): 1.89e-57: 193: 27.20		SSBP3_HUMAN (1-388): 5.14e-67: 218: 100.00
+	Hs
		1314903 LHX9_HUMAN (10-313): 6.31e-57: 192: 26.33		SSBP3_HUMAN (1-388): 5.14e-67: 218: 100.00
+	Hs
		839818 LHX2_HUMAN (24-326): 1.89e-57: 193: 27.20		SSBP4_HUMAN (5-388): 9.47e-57: 192: 69.25
+	Hs
		1314654 LHX9_HUMAN (10-313): 6.31e-57: 192: 26.33		SSBP4_HUMAN (5-388): 9.47e-57: 192: 69.25
+	Mm
		1112385 LHX9_MOUSE (10-313): 9.15e-57: 191: 26.33		Q3U4B1_MOUSE (1-388): 1.81e-48: 169: 62.66
+	Mm
		1321891 LHX2_MOUSE (24-326): 2.86e-58: 195: 27.76		SSBP2_MOUSE (3-388): 9.79e-45: 159: 77.00
+	Hs
		839725 LHX2_HUMAN (24-326): 1.89e-57: 193: 27.20		SSBP2_HUMAN (3-388): 2.7e-44: 158: 77.26
+	Mm
		1321890 LHX9_MOUSE (10-313): 9.15e-57: 191: 26.33		SSBP2_MOUSE (3-388): 9.79e-45: 159: 77.00
+	Hs
		839836 LHX2_HUMAN (24-326): 1.89e-57: 193: 27.20		CHD7_HUMAN (99-332): 1.72e-32: 131: 17.60