Protein: OTU7B
OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne)

Gene: OTU7B, OTUD7B
Organism: Homo sapiens
Interactions: 113
UniProt ID: Q6GQQ9

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001701 - in utero embryonic development
GO:0002250 - adaptive immune response
GO:0002385 - mucosal immune response
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508138

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

14

11

Small-scale

0.983

High

1232973

OTU7A
OTU domain-containing protein 7A

2

4

Small-scale

0.789

High

507230

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

11

Small-scale

0.759

High

1232989

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

5

5

Small-scale

0.718

High

170198

AURKA
Aurora kinase A

3

6

Small-scale

0.674

High

241996

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.665

High

856738

BAG6
Large proline-rich protein BAG6

1

11

High-throughput

0.665

High

1232994

UBQL1
Ubiquilin-1

1

7

High-throughput

0.665

High

1162674

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

8

Small-scale

0.647

High

1232976

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

3

High-throughput

0.634

High

132100

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

6

Small-scale

0.611

High

1232972

TNIP2
TNFAIP3-interacting protein 2

2

2

Small-scale

0.606

High

633716

PSB1
Proteasome subunit beta type-1

2

10

High-throughput

0.606

High

1232962

EPMIP
EPM2A-interacting protein 1

2

2

High-throughput

0.606

High

1232970

SPART
Spartin

2

6

High-throughput

0.606

High

1232979

HSFY1
Heat shock transcription factor, Y-linked

2

1

High-throughput

0.606

High

1232987

CDIP1
Cell death-inducing p53-target protein 1

2

2

High-throughput

0.606

High

862218

YAP1
Transcriptional coactivator YAP1

2

9

Small-scale

0.584

High

1107825

SQSTM
Sequestosome-1

2

6

Small-scale

0.584

High

1139059

DAZP2
DAZ-associated protein 2

2

0

High-throughput

0.580

High

1232964

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.580

High

1232978

OTUL
Ubiquitin thioesterase otulin

2

0

High-throughput

0.580

High

573842

CCNB1
G2/mitotic-specific cyclin-B1

1

1

Small-scale

0.578

High

396316

ESR1
Estrogen receptor

1

2

Small-scale

0.561

High

872433

SOX2
Transcription factor SOX-2

1

4

Small-scale

0.561

High

1086866

CDC20
Cell division cycle protein 20 homolog

1

6

Small-scale

0.561

High

1232971

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

2

Small-scale

0.561

High

1232993

FZR1
Fizzy-related protein homolog

1

4

Small-scale

0.561

High

291383

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.536

High

1150437

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

10

High-throughput

0.536

High

1232977

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.536

High

1232988

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

6

High-throughput

0.536

High

1232981

PARK7
Parkinson disease protein 7

1

1

Small-scale

0.534

High

1232969

CCD50
Coiled-coil domain-containing protein 50

1

2

Small-scale

0.529

High

1232996

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.515

High

167285

KLF11
Krueppel-like factor 11

1

12

High-throughput

0.515

High

216718

HTRA2
Serine protease HTRA2, mitochondrial

1

2

High-throughput

0.515

High

245981

KIF1B
Kinesin-like protein KIF1B

1

8

High-throughput

0.515

High

282597

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

4

High-throughput

0.515

High

301482

WFS1
Wolframin

1

1

High-throughput

0.515

High

361278

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.515

High

390075

ALBU
Albumin

1

3

High-throughput

0.515

High

415641

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.515

High

442360

GELS
Gelsolin

1

4

High-throughput

0.515

High

479603

DOPO
Dopamine beta-hydroxylase

1

1

High-throughput

0.515

High

570457

GFAP
Glial fibrillary acidic protein

1

5

High-throughput

0.515

High

691774

MK03
Mitogen-activated protein kinase 3

1

3

High-throughput

0.515

High

767240

MERL
Merlin

1

9

High-throughput

0.515

High

791461

SYUA
Alpha-synuclein

1

1

High-throughput

0.515

High

832059

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

6

High-throughput

0.515

High

904833

MECP2
Methyl-CpG-binding protein 2

1

6

High-throughput

0.515

High

930938

HSP72
Heat shock-related 70 kDa protein 2

1

2

High-throughput

0.515

High

937033

CASP6
Caspase-6

1

6

High-throughput

0.515

High

954504

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

4

High-throughput

0.515

High

981543

RAN
GTP-binding nuclear protein Ran

1

8

High-throughput

0.515

High

1096047

TADBP
TAR DNA-binding protein 43

1

7

High-throughput

0.515

High

1123674

DCTN1
Dynactin subunit 1

1

10

High-throughput

0.515

High

1232965

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

2

High-throughput

0.515

High

1232995

RNF11
RING finger protein 11

1

4

High-throughput

0.515

High

1232968

ZDH17
Palmitoyltransferase ZDHHC17

1

12

High-throughput

0.494

High

159977

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.493

High

165769

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

High-throughput

0.493

High

927354

ATX1
Ataxin-1

1

0

High-throughput

0.493

High

1232961

MTSS2
Protein MTSS 2

1

3

High-throughput

0.489

High

1232960

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.480

High

246680

KDM1A
Lysine-specific histone demethylase 1A

1

4

Small-scale

0.479

High

279178

ULK1
Serine/threonine-protein kinase ULK1

1

8

Small-scale

0.479

High

363419

EGFR
Epidermal growth factor receptor

1

3

Small-scale

0.479

High

372292

MYC
Myc proto-oncogene protein

1

3

Small-scale

0.479

High

764833

CTNB1
Catenin beta-1

1

8

Small-scale

0.479

High

827204

ARL1
ADP-ribosylation factor-like protein 1

1

7

High-throughput

0.479

High

830916

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

857478

NOTC1
Neurogenic locus notch homolog protein 1

1

11

Small-scale

0.479

High

1061591

FOXM1
Forkhead box protein M1

1

5

Small-scale

0.479

High

1094911

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

1113393

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1126704

BECN1
Beclin-1

1

1

Small-scale

0.479

High

1129149

IRF3
Interferon regulatory factor 3

1

3

Small-scale

0.479

High

1132377

CASP8
Caspase-8

1

6

Small-scale

0.479

High

1161305

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.479

High

1232959

ANO7
Anoctamin-7

1

1

Small-scale

0.479

High

1232966

TAXB1
Tax1-binding protein 1

1

11

Small-scale

0.479

High

1232982

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

9

Small-scale

0.479

High

1232983

EPAS1
Endothelial PAS domain-containing protein 1

1

2

Small-scale

0.479

High

1232984

LST8
Target of rapamycin complex subunit LST8

1

4

Small-scale

0.479

High

1232991

WWOX
WW domain-containing oxidoreductase

1

3

High-throughput

0.479

High

1232992

LEF1
Lymphoid enhancer-binding factor 1

1

5

Small-scale

0.479

High

109422

G5E9A7
DM1 locus, WD repeat containing

1

6

High-throughput

0.470

High

280667

PR40A
Pre-mRNA-processing factor 40 homolog A

1

12

High-throughput

0.470

High

369686

A2MG
Alpha-2-macroglobulin

1

5

High-throughput

0.470

High

389836

TTHY
Transthyretin

1

1

High-throughput

0.470

High

562136

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.470

High

622184

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

1

High-throughput

0.470

High

650227

FGFR3
Fibroblast growth factor receptor 3

1

3

High-throughput

0.470

High

1081538

Q0VDC6
peptidylprolyl isomerase

1

5

High-throughput

0.470

High

1133883

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

2

High-throughput

0.470

High

1232985

NUP58
Nucleoporin p58/p45

1

2

High-throughput

0.470

High

270728

N4BP1
NEDD4-binding protein 1

1

0

Small-scale

0.458

High

870648

MAOX
NADP-dependent malic enzyme

1

0

Small-scale

0.458

High

729943

1433B
14-3-3 protein beta/alpha

1

19

Small-scale

0.457

High

127690

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

7

Small-scale

0.445

High

1232980

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

8

High-throughput

0.445

High

465550

IGF1R
Insulin-like growth factor 1 receptor

1

3

Small-scale

0.437

High

622627

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

7

Small-scale

0.437

High

1232963

MAVS
Mitochondrial antiviral-signaling protein

1

7

Small-scale

0.437

High

1232990

RHBL2
Rhomboid-related protein 2

1

1

Small-scale

0.437

High

1232975

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low

47344

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

1232967

Q86WV8
TSC complex subunit 1

1

0

High-throughput

0.268

Low

1232974

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

1232997

Q9Y649
GW128

1

0

High-throughput

0.268

Low

106106

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1232986

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025