HitPredict

Interactor 1: EFMT3 (Q96AZ1)
EEF1A lysine methyltransferase 3 (EC 2.1.1.-) (Hepatocellular carcinoma-associated antigen 557a) (Methyltransferase-like protein 21B) (Protein-lysine methyltransferase METTL21B) (eEF1A-KMT3)
Gene: EEF1AKMT3

Interactor 2: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 226 Hs			1 1374
+	Hs
		1305586 ANM1_HUMAN (16-205): 2.89e-20: 89.7: 15.27		M3K5_HUMAN (1-1374): 0: 1497: 100.00
+	Hs
		312808 EFMT3_HUMAN (1-226): 3.13e-90: 266: 100.00		M3K6_HUMAN (27-1374): 0: 1171: 43.67
+	Hs
		850693 EFMT3_HUMAN (1-226): 3.13e-90: 266: 100.00		KS6A3_HUMAN (623-1074): 1.34e-117: 387: 19.83
+	Hs
		1071671 EFMT3_HUMAN (1-226): 3.13e-90: 266: 100.00		KS6A2_HUMAN (673-1074): 1.52e-117: 386: 20.91
+	Hs
		270436 EFMT3_HUMAN (1-226): 3.13e-90: 266: 100.00		KS6A5_HUMAN (673-1088): 5.06e-109: 365: 19.51
+	Mm
		1161537 MT21E_MOUSE (33-226): 1.21e-59: 189: 35.15		KCC2D_MOUSE (678-995): 1.4e-97: 324: 26.53
+	Hs
		681970 EFMT3_HUMAN (1-226): 3.13e-90: 266: 100.00		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64