HitPredict

Interactor 1: PF21A (Q96BD5)
PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)
Gene: PHF21A

Interactor 2: HM20A (Q9NP66)
High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1)
Gene: HMG20A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.720

Property	Details
Experiments	26496610, 28514442, 27173435, 25639869, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003677 - DNA binding GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 680 Hs			1 347
+	Hs
		1285376 PF21A_HUMAN (1-680): 2.54e-112: 355: 100.00		HM20B_HUMAN (60-345): 5.54e-68: 217: 50.00
+	Hs
		1285335 PF21A_HUMAN (1-680): 2.54e-112: 355: 100.00		CIC_HUMAN (27-227): 1.8e-32: 130: 17.24
+	Hs
		297535 PF21A_HUMAN (1-680): 2.54e-112: 355: 100.00		TOX4_HUMAN (4-265): 3.04e-29: 120: 15.99
+	Hs
		1281264 TRI33_HUMAN (2-648): 1.4e-85: 293: 16.08		SMCE1_HUMAN (109-299): 6.51e-34: 130: 20.00
+	Hs
		996961 TRI33_HUMAN (2-648): 1.4e-85: 293: 16.08		SSRP1_HUMAN (1-266): 7.41e-32: 128: 16.30
+	Hs
		818613 TRI33_HUMAN (2-648): 1.4e-85: 293: 16.08		SOX2_HUMAN (68-269): 3.13e-31: 121: 15.42
+	Hs
		1332331 TRI33_HUMAN (2-648): 1.4e-85: 293: 16.08		SOX17_HUMAN (14-208): 2.05e-29: 118: 15.90
+	Hs
		170345 TIF1A_HUMAN (2-647): 1.34e-77: 270: 14.56		SSRP1_HUMAN (1-266): 7.41e-32: 128: 16.30
+	Hs
		170296 TIF1A_HUMAN (2-647): 1.34e-77: 270: 14.56		SOX2_HUMAN (68-269): 3.13e-31: 121: 15.42
+	Hs
		170476 TIF1A_HUMAN (2-647): 1.34e-77: 270: 14.56		SOX17_HUMAN (14-208): 2.05e-29: 118: 15.90
+	Hs
		297467 KDM5C_HUMAN (169-655): 3.08e-60: 221: 15.75		TOX4_HUMAN (4-265): 3.04e-29: 120: 15.99
+	Mm
		818732 KDM5B_MOUSE (139-656): 9.66e-59: 217: 14.83		SOX2_MOUSE (65-269): 5.13e-31: 121: 15.21
+	Hs
		1300981 BAZ2A_HUMAN (4-648): 1.81e-50: 192: 11.71		CIC_HUMAN (27-227): 1.8e-32: 130: 17.24
+	Hs
		1059778 CHD4_HUMAN (324-650): 1.2e-41: 165: 16.04		SMCE1_HUMAN (109-299): 6.51e-34: 130: 20.00
+	Hs
		1059807 CHD4_HUMAN (324-650): 1.2e-41: 165: 16.04		CIC_HUMAN (27-227): 1.8e-32: 130: 17.24
+	Hs
		996673 CHD4_HUMAN (324-650): 1.2e-41: 165: 16.04		SSRP1_HUMAN (1-266): 7.41e-32: 128: 16.30
+	Hs
		818573 BAZ2B_HUMAN (2-648): 3.37e-43: 170: 12.25		SOX2_HUMAN (68-269): 3.13e-31: 121: 15.42
+	Hs
		818056 CHD4_HUMAN (324-650): 1.2e-41: 165: 16.04		SOX2_HUMAN (68-269): 3.13e-31: 121: 15.42
+	Mm
		818727 CHD4_MOUSE (324-650): 3.17e-41: 164: 16.04		SOX2_MOUSE (65-269): 5.13e-31: 121: 15.21
+	Hs
		567697 CHD4_HUMAN (324-650): 1.2e-41: 165: 16.04		UBF1_HUMAN (59-266): 2.79e-09: 60.4: 16.35