HitPredict

Interactor 1: PF21A (Q96BD5)
PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)
Gene: PHF21A

Interactor 2: RCOR1 (Q9UKL0)
REST corepressor 1 (Protein CoREST)
Gene: RCOR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.728

Property	Details
Experiments	12032298, 34709266, 27173435, 15325272, 33961781, 26751641
Identification Methods	biochemical, proximity labelling technology, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000118 - histone deacetylase complex GO:0003682 - chromatin binding GO:0005654 - nucleoplasm GO:0006325 - chromatin organization GO:1990391 - DNA repair complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 680 Hs			1 485
+	Hs
		1285378 PF21A_HUMAN (1-680): 2.54e-112: 355: 100.00		RCOR3_HUMAN (105-480): 6.86e-123: 369: 63.08
+	Hs
		1223938 PF21A_HUMAN (1-680): 2.54e-112: 355: 100.00		RCOR2_HUMAN (70-482): 4.1e-111: 340: 52.96
+	Hs
		164501 TRI66_HUMAN (2-647): 2.96e-69: 248: 14.35		RCOR1_HUMAN (1-485): 5.94e-148: 433: 100.00
+	Hs
		1355123 KDM5B_HUMAN (147-656): 5.55e-61: 224: 13.90		RCOR1_HUMAN (1-485): 5.94e-148: 433: 100.00
+	Hs
		170419 TIF1A_HUMAN (2-647): 1.34e-77: 270: 14.56		RCOR2_HUMAN (70-482): 4.1e-111: 340: 52.96
+	Hs
		1312037 KDM5B_HUMAN (147-656): 5.55e-61: 224: 13.90		MTA3_HUMAN (80-485): 5.88e-92: 293: 17.42
+	Mm
		56904 CHD5_MOUSE (255-617): 1.37e-48: 186: 16.33		MTA3_MOUSE (80-463): 7.34e-92: 292: 17.90
+	Hs
		1255042 CHD5_HUMAN (255-617): 2.01e-43: 170: 16.79		MTA3_HUMAN (80-485): 5.88e-92: 293: 17.42
+	Hs
		296164 KDM5B_HUMAN (147-656): 5.55e-61: 224: 13.90		MTA2_HUMAN (85-446): 1.69e-64: 222: 16.67
+	Hs
		1031911 CHD5_HUMAN (255-617): 2.01e-43: 170: 16.79		MTA1_HUMAN (81-410): 5.09e-71: 241: 16.03
+	Hs
		1031857 CHD4_HUMAN (324-650): 1.2e-41: 165: 16.04		MTA1_HUMAN (81-410): 5.09e-71: 241: 16.03
+	Dm
		332872 CHDM_DROME (173-626): 2.63e-48: 185: 16.10		Q9VNF6_DROME (80-406): 9.51e-61: 215: 15.95
+	Dm
		81419 CHDM_DROME (173-626): 2.63e-48: 185: 16.10		B7Z0T5_DROME (80-406): 6.45e-61: 215: 15.95
+	Hs
		296083 CHD5_HUMAN (255-617): 2.01e-43: 170: 16.79		MTA2_HUMAN (85-446): 1.69e-64: 222: 16.67
+	Hs
		296024 CHD4_HUMAN (324-650): 1.2e-41: 165: 16.04		MTA2_HUMAN (85-446): 1.69e-64: 222: 16.67
+	Hs
		261613 TRI33_HUMAN (2-648): 1.4e-85: 293: 16.08		NCOR1_HUMAN (194-465): 5.18e-11: 67.4: 12.86
+	Hs
		261606 KDM5B_HUMAN (147-656): 5.55e-61: 224: 13.90		NCOR1_HUMAN (194-465): 5.18e-11: 67.4: 12.86
+	Hs
		261428 KDM5C_HUMAN (169-655): 3.08e-60: 221: 15.75		NCOR1_HUMAN (194-465): 5.18e-11: 67.4: 12.86
+	Ce
		1094912 CHD3_CAEEL (296-652): 1.08e-47: 184: 16.41		Q86S28_CAEEL (127-263): 2.76e-19: 93.1: 17.28
+	Ce
		104628 LE418_CAEEL (296-652): 1.28e-44: 174: 16.67		Q86S28_CAEEL (127-263): 2.76e-19: 93.1: 17.28