HitPredict

Interactor 1: OTUL (Q96BN8)
Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby)
Gene: OTULIN

Interactor 2: SNX27 (Q96L92)
Sorting nexin-27
Gene: SNX27

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.938

Property	Details
Experiments	31541095, 34315543, 35271311, 36398858, 37589075
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PDZ~Peptidase_C101
Common GO terms	GO:0005829 - cytosol
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 352 Hs			1 541
+	Hs
		1075439 OTUL_HUMAN (1-352): 0: 630: 100.00		NHRF2_HUMAN (9-207): 1.8e-24: 106: 21.78
+	Hs
		153940 OTUL_HUMAN (1-352): 0: 630: 100.00		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Hs
		1132913 OTUL_HUMAN (1-352): 0: 630: 100.00		NHRF3_HUMAN (38-313): 4.98e-16: 82.7: 13.70
+	Hs
		67918 OTUL_HUMAN (1-352): 0: 630: 100.00		PDZ1P_HUMAN (38-282): 1.35e-15: 80.7: 14.23