HitPredict

Interactor 1: DHX58 (Q96C10)
ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR)
Gene: DHX58

Interactor 2: AGO2 (Q9UKV8)
Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Gene: AGO2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	21903422
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003725 - double-stranded RNA binding GO:0003727 - single-stranded RNA binding GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 678 Hs			1 859
+	Mm
		1208646 DICER_MOUSE (3-558): 4.58e-91: 312: 22.35		AGO2_MOUSE (1-859): 0: 1219: 99.19
+	Hs
		1356627 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		1356717 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		1334291 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		AGO3_HUMAN (5-859): 0: 1165: 79.75
+	Hs
		1336290 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		AGO4_HUMAN (16-859): 0: 1145: 78.51
+	Hs
		134247 DDX3X_HUMAN (146-516): 5.67e-56: 203: 16.67		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Ce
		108452 DCR1_CAEEL (1-558): 1.33e-86: 299: 19.69		G5EGR6_CAEEL (19-859): 0: 1102: 67.09
+	Ce
		184082 DCR1_CAEEL (1-558): 1.33e-86: 299: 19.69		O16720_CAEEL (3-859): 0: 1089: 65.63
+	Ce
		106110 G5EDI8_CAEEL (3-664): 1.16e-73: 258: 23.41		G5EGR6_CAEEL (19-859): 0: 1102: 67.09
+	Hs
		571629 DDX5_HUMAN (2-255): 1.99e-37: 150: 15.21		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		571630 DDX5_HUMAN (2-255): 1.99e-37: 150: 15.21		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		757796 IF4A3_HUMAN (2-345): 5e-28: 118: 8.96		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		1294948 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		PIWL1_HUMAN (23-826): 0: 751: 22.45
+	Mm
		1246887 DICER_MOUSE (3-558): 4.58e-91: 312: 22.35		PIWL1_MOUSE (23-826): 0: 744: 22.09
+	Hs
		1253320 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		PIWL2_HUMAN (5-821): 0: 735: 21.74
+	Hs
		1189714 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		PIWL4_HUMAN (22-822): 0: 686: 22.07
+	Hs
		1189708 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		PIWL3_HUMAN (24-827): 0: 670: 21.81
+	Dm
		55504 DCR2_DROME (1-562): 2.44e-73: 260: 17.96		AGO2_DROME (30-818): 0: 713: 31.09
+	Ce
		106844 DCR1_CAEEL (1-558): 1.33e-86: 299: 19.69		G5EEH0_CAEEL (314-822): 2.74e-45: 178: 27.59
+	Ce
		106109 G5EDI8_CAEEL (3-664): 1.16e-73: 258: 23.41		G5EEH0_CAEEL (314-822): 2.74e-45: 178: 27.59