HitPredict

Interactor 1: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Interactor 2: DYL2 (Q96FJ2)
Dynein light chain 2, cytoplasmic (8 kDa dynein light chain b) (DLC8b) (Dynein light chain LC8-type 2)
Gene: DYNLL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 577 Hs			1 89
+	Hs
		928422 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		DYL1_HUMAN (1-89): 1.8e-47: 147: 93.26
+	Hs
		928294 DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58		DYL1_HUMAN (1-89): 1.8e-47: 147: 93.26
+	Hs
		1051400 DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58		DYL2_HUMAN (1-89): 7.09e-47: 146: 100.00
+	Hs
		551662 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		DYL1_HUMAN (1-89): 1.8e-47: 147: 93.26
+	Hs
		928303 NUMA1_HUMAN (4-572): 1.29e-14: 79.5: 12.87		DYL1_HUMAN (1-89): 1.8e-47: 147: 93.26
+	Hs
		148656 CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59		DYL1_HUMAN (1-89): 1.8e-47: 147: 93.26