HitPredict

Interactor 1: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Interactor 2: REPS1 (Q96D71)
RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)
Gene: REPS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	33961781, 26186194, 28514442, 19380743, 24189400
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 435 Hs			1 796
+	Hs
		1287515 AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00		ITSN2_HUMAN (4-793): 2.76e-89: 310: 12.97
+	Hs
		1244783 AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00		REPS2_HUMAN (4-796): 3.9e-87: 291: 32.23
+	Hs
		1287519 AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00		EP15R_HUMAN (8-735): 2e-72: 256: 13.93
+	Dm
		112641 O62530_DROME (1-435): 7.78e-171: 487: 86.56		M9NDL7_DROME (4-715): 5.2e-57: 212: 21.26
+	Hs
		1357371 AP1M2_HUMAN (2-434): 5.35e-163: 467: 37.70		SYNRG_HUMAN (15-788): 4.39e-54: 205: 10.71
+	Hs
		1287516 AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00		EHD2_HUMAN (256-370): 1e-40: 159: 33.91
+	Hs
		1349325 AP1M2_HUMAN (2-434): 5.35e-163: 467: 37.70		EHD2_HUMAN (256-370): 1e-40: 159: 33.91
+	Hs
		1078888 AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00		ITSN1_HUMAN (1-115): 1.23e-17: 90.4: 16.52
+	Hs
		787959 AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00		EPS15_HUMAN (4-782): 1.98e-17: 89.3: 10.12
+	Hs
		1263427 STON2_HUMAN (146-433): 1.58e-62: 219: 22.85		REPS1_HUMAN (1-796): 2.33e-108: 351: 100.00
+	Ce
		725368 AP2M_CAEEL (1-435): 3.73e-172: 491: 80.95		Q9U2T9_CAEEL (1-119): 4.74e-11: 68.9: 16.41
+	Hs
		1263440 STON2_HUMAN (146-433): 1.58e-62: 219: 22.85		EP15R_HUMAN (8-735): 2e-72: 256: 13.93
+	Dm
		91158 STNB_DROME (118-433): 1.17e-60: 215: 18.80		E3CTP7_DROME (1-695): 1.93e-74: 260: 11.95
+	Hs
		1263435 STON2_HUMAN (146-433): 1.58e-62: 219: 22.85		EHD1_HUMAN (269-370): 3.03e-40: 157: 38.24
+	Hs
		1078883 STON2_HUMAN (146-433): 1.58e-62: 219: 22.85		ITSN1_HUMAN (1-115): 1.23e-17: 90.4: 16.52
+	Hs
		787954 STON2_HUMAN (146-433): 1.58e-62: 219: 22.85		EPS15_HUMAN (4-782): 1.98e-17: 89.3: 10.12
+	Rn
		64454 Q7TNJ9_RAT (127-408): 1.81e-58: 205: 23.26		A7BFV9_RAT (4-118): 2.62e-11: 69.3: 24.35