Protein: STIM2
Stromal interaction molecule 2

Gene: STIM2
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q9P246

Gene Ontology (top 5):
GO:0002115 - store-operated calcium entry
GO:0005246 - calcium channel regulator activity
GO:0005509 - calcium ion binding
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1111736

STIM1
Stromal interaction molecule 1

5

4

Small-scale

0.930

High

930809

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

4

4

High-throughput

0.638

High

1327992

CISD2
CDGSH iron-sulfur domain-containing protein 2

2

1

High-throughput

0.628

High

710534

EPHA2
Ephrin type-A receptor 2

1

9

High-throughput

0.618

High

1004223

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.618

High

225712

AAKB2
5'-AMP-activated protein kinase subunit beta-2

3

1

High-throughput

0.616

High

1095472

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

3

4

High-throughput

0.609

High

1333638

SUMF1
Formylglycine-generating enzyme

2

0

High-throughput

0.602

High

845837

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.586

High

376043

RASK
GTPase KRas

2

6

High-throughput

0.584

High

1404254

SEC62
Translocation protein SEC62

2

1

High-throughput

0.584

High

1454270

ALK
ALK tyrosine kinase receptor

2

17

High-throughput

0.584

High

930376

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

2

1

High-throughput

0.574

High

1454266

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

2

1

High-throughput

0.574

High

1454275

AAKB1
5'-AMP-activated protein kinase subunit beta-1

2

1

High-throughput

0.574

High

966965

1433G
14-3-3 protein gamma

2

9

High-throughput

0.558

High

341370

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.536

High

409622

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

4

High-throughput

0.536

High

438917

CD1A
T-cell surface glycoprotein CD1a

1

4

High-throughput

0.536

High

483977

HMOX1
Heme oxygenase 1

1

2

High-throughput

0.536

High

548138

PSPC
Surfactant protein C

1

1

High-throughput

0.536

High

720066

HMOX2
Heme oxygenase 2

1

2

High-throughput

0.536

High

972084

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.536

High

1126380

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

1

High-throughput

0.536

High

1128495

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

1

High-throughput

0.536

High

1382082

T106A
Transmembrane protein 106A

1

1

High-throughput

0.536

High

1392308

ZDH12
Palmitoyltransferase ZDHHC12

1

1

High-throughput

0.536

High

1438716

CRLF2
Cytokine receptor-like factor 2

1

2

High-throughput

0.536

High

1327804

SH2D3
SH2 domain-containing protein 3C

2

1

High-throughput

0.521

High

1312658

MSRB3
Methionine-R-sulfoxide reductase B3

1

0

High-throughput

0.513

High

730310

1433B
14-3-3 protein beta/alpha

1

9

High-throughput

0.489

High

990815

1433Z
14-3-3 protein zeta/delta

1

9

High-throughput

0.489

High

1410485

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

1

1

High-throughput

0.489

High

1419897

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

1

High-throughput

0.489

High

48832

ESYT2
Extended synaptotagmin-2

1

3

High-throughput

0.479

High

174133

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

2

High-throughput

0.479

High

189892

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

218891

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

226238

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

417818

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

418485

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

439867

INSR
Insulin receptor

1

18

High-throughput

0.479

High

464069

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

11

High-throughput

0.479

High

465676

IGF1R
Insulin-like growth factor 1 receptor

1

19

High-throughput

0.479

High

466505

RHOC
Rho-related GTP-binding protein RhoC

1

13

High-throughput

0.479

High

541730

FGFR1
Fibroblast growth factor receptor 1

1

12

High-throughput

0.479

High

548380

CP2C9
Cytochrome P450 2C9

1

1

High-throughput

0.479

High

581346

RAC2
Ras-related C3 botulinum toxin substrate 2

1

12

High-throughput

0.479

High

604251

CXA1
Gap junction alpha-1 protein

1

3

High-throughput

0.479

High

611398

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

630654

RAB3B
Ras-related protein Rab-3B

1

2

High-throughput

0.479

High

643111

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.479

High

699213

CALX
Calnexin

1

2

High-throughput

0.479

High

715820

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

847730

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.479

High

880727

LMAN1
Protein ERGIC-53

1

1

High-throughput

0.479

High

895124

EMD
Emerin

1

1

High-throughput

0.479

High

901635

RAB7A
Ras-related protein Rab-7a

1

5

High-throughput

0.479

High

902118

RAB9A
Ras-related protein Rab-9A

1

6

High-throughput

0.479

High

904173

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.479

High

910235

RND2
Rho-related GTP-binding protein RhoN

1

18

High-throughput

0.479

High

951485

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

953726

RAC3
Ras-related C3 botulinum toxin substrate 3

1

13

High-throughput

0.479

High

955702

CDC42
Cell division control protein 42 homolog

1

13

High-throughput

0.479

High

962584

RHOA
Transforming protein RhoA

1

14

High-throughput

0.479

High

978367

RHOB
Rho-related GTP-binding protein RhoB

1

14

High-throughput

0.479

High

1015871

RHOG
Rho-related GTP-binding protein RhoG

1

12

High-throughput

0.479

High

1027224

REEP5
Receptor expression-enhancing protein 5

1

2

High-throughput

0.479

High

1034365

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

18

High-throughput

0.479

High

1049855

1433F
14-3-3 protein eta

1

9

High-throughput

0.479

High

1055107

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

17

High-throughput

0.479

High

1058703

CKAP4
Cytoskeleton-associated protein 4

1

1

High-throughput

0.479

High

1087324

STX4
Syntaxin-4

1

4

High-throughput

0.479

High

1125713

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

1

High-throughput

0.479

High

1145146

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.479

High

1157097

NTRK3
NT-3 growth factor receptor

1

18

High-throughput

0.479

High

1163436

CAH9
Carbonic anhydrase 9

1

1

High-throughput

0.479

High

1287459

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

High-throughput

0.479

High

1309910

TEX2
Testis-expressed protein 2

1

1

High-throughput

0.479

High

1323025

CXD3
Gap junction delta-3 protein

1

3

High-throughput

0.479

High

1334046

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.479

High

1337704

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.479

High

1352386

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.479

High

1383132

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

1395975

DNJC1
DnaJ homolog subfamily C member 1

1

5

High-throughput

0.479

High

1401248

PANX1
Pannexin-1

1

1

High-throughput

0.479

High

1401721

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

2

High-throughput

0.479

High

1403819

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.479

High

1412707

ESYT1
Extended synaptotagmin-1

1

3

High-throughput

0.479

High

1414488

DERL1
Derlin-1

1

1

High-throughput

0.479

High

1421169

LNP
Endoplasmic reticulum junction formation protein lunapark

1

2

High-throughput

0.479

High

1431275

DJC25
DnaJ homolog subfamily C member 25

1

5

High-throughput

0.479

High

1431777

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.479

High

1436347

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

1438213

RHOF
Rho-related GTP-binding protein RhoF

1

16

High-throughput

0.479

High

1447902

SAR1A
Small COPII coat GTPase SAR1A

1

6

High-throughput

0.479

High

1452715

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.479

High

1454265

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.479

High

1454267

SEC63
Translocation protein SEC63 homolog

1

3

High-throughput

0.479

High

1454272

DJC16
DnaJ homolog subfamily C member 16

1

3

High-throughput

0.479

High

1454276

SAR1B
Small COPII coat GTPase SAR1B

1

5

High-throughput

0.479

High

913076

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

0

High-throughput

0.458

High

1119644

KGP1
cGMP-dependent protein kinase 1

1

0

High-throughput

0.458

High

1229115

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

291575

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.437

High

634676

LMNB1
Lamin-B1

1

2

High-throughput

0.437

High

837883

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.437

High

1252269

SYNE3
Nesprin-3

1

3

High-throughput

0.437

High

1293185

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1382970

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.437

High

1435390

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

1448033

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.437

High

1448164

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.437

High

1450121

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

1454269

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.437

High

1454271

MARE3
Microtubule-associated protein RP/EB family member 3

1

2

High-throughput

0.437

High

1454274

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

1

High-throughput

0.437

High

1454273

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.426

High

1260500

BRNP3
BMP/retinoic acid-inducible neural-specific protein 3

2

0

High-throughput

0.328

High

1450538

TMLH
Trimethyllysine dioxygenase, mitochondrial

2

0

High-throughput

0.328

High

800432

LICH
Lysosomal acid lipase/cholesteryl ester hydrolase

1

0

High-throughput

0.279

Low

1194514

NADK2
NAD kinase 2, mitochondrial

1

0

High-throughput

0.279

Low

1272076

SYPM
Probable proline--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

1357804

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

1454268

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.279

Low

280851

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.265

Low

1140966

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1289325

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.249

Low

1057012

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025