HitPredict

Interactor 1: VWCE (Q96DN2)
von Willebrand factor C and EGF domain-containing protein (HBV X protein up-regulated gene 11 protein) (HBxAg up-regulated gene 11 protein)
Gene: VWCE

Interactor 2: EGFL7 (Q9UHF1)
Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)
Gene: EGFL7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005576 - extracellular region
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 955 Hs			1 273
+	Hs
		980568 NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27		EGFL7_HUMAN (1-273): 1.56e-39: 140: 100.00
+	Mm
		192834 NOTC2_MOUSE (214-829): 1.21e-38: 159: 11.71		EGFL7_MOUSE (1-272): 1.11e-36: 133: 78.10
+	Hs
		1354452 FBLN5_HUMAN (61-281): 2.58e-37: 148: 30.21		EGFL7_HUMAN (1-273): 1.56e-39: 140: 100.00
+	Mm
		681672 NOTC4_MOUSE (224-873): 2.38e-31: 135: 10.36		EGFL7_MOUSE (1-272): 1.11e-36: 133: 78.10
+	Hs
		537510 NID1_HUMAN (92-351): 1.12e-45: 180: 27.27		NID1_HUMAN (60-238): 6.36e-16: 79.5: 17.59
+	Hs
		1355435 NOTC3_HUMAN (1-511): 7.1e-24: 111: 14.21		EGFL7_HUMAN (1-273): 1.56e-39: 140: 100.00
+	Mm
		1143214 NOTC3_MOUSE (1-526): 2.82e-25: 115: 13.53		EGFL7_MOUSE (1-272): 1.11e-36: 133: 78.10
+	Hs
		537518 NID1_HUMAN (92-351): 1.12e-45: 180: 27.27		NID2_HUMAN (4-190): 1.14e-09: 60.6: 14.49
+	Hs
		296652 NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27		SLIT2_HUMAN (3-138): 1.42e-12: 69.5: 11.77
+	Hs
		980413 NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27		NPNT_HUMAN (80-173): 1.51e-11: 65.9: 32.35
+	Hs
		944119 NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27		JAG1_HUMAN (66-168): 1.68e-10: 63.2: 28.57
+	Hs
		804213 NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Hs
		1354450 FBLN5_HUMAN (61-281): 2.58e-37: 148: 30.21		FBLN5_HUMAN (13-187): 8.52e-09: 57.5: 17.46
+	Dm
		90684 NOTCH_DROME (1-566): 1.91e-28: 126: 12.46		E1JHA6_DROME (2-138): 3.95e-12: 68.3: 13.61
+	Dm
		422709 NOTCH_DROME (1-566): 1.91e-28: 126: 12.46		NOTCH_DROME (68-172): 9.27e-10: 61: 22.32
+	Dm
		422713 NOTCH_DROME (1-566): 1.91e-28: 126: 12.46		DL_DROME (53-168): 1.69e-09: 60.1: 25.58
+	Hs
		804379 JAG2_HUMAN (209-851): 1.57e-28: 125: 10.62		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Hs
		944134 NOTC3_HUMAN (1-511): 7.1e-24: 111: 14.21		JAG1_HUMAN (66-168): 1.68e-10: 63.2: 28.57
+	Hs
		804372 NOTC3_HUMAN (1-511): 7.1e-24: 111: 14.21		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Hs
		624332 TENA_HUMAN (3-265): 9.93e-22: 104: 14.13		NID2_HUMAN (4-190): 1.14e-09: 60.6: 14.49