HitPredict

Interactor 1: SPDLY (Q96EA4)
Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1)
Gene: SPDL1

Interactor 2: UBP15 (Q9Y4E8)
Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)
Gene: USP15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.644

Property	Details
Experiments	25416956, 33961781
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 605 Hs			1 981
+	Mm
		1186813 MRCKB_MOUSE (5-542): 4.87e-73: 257: 18.02		UBP15_MOUSE (1-981): 0: 858: 97.66
+	Hs
		1024396 SPDLY_HUMAN (1-605): 2.11e-78: 261: 100.00		UBP4_HUMAN (1-981): 0: 794: 55.38
+	Mm
		1246962 MYH9_MOUSE (4-596): 2.21e-17: 88.7: 13.91		UBP15_MOUSE (1-981): 0: 858: 97.66
+	Hs
		725273 MYH10_HUMAN (4-596): 7.47e-17: 87.1: 11.71		UBP15_HUMAN (1-981): 0: 859: 100.00
+	Mm
		1143171 MYH10_MOUSE (4-596): 2.89e-16: 85.2: 12.03		UBP15_MOUSE (1-981): 0: 858: 97.66
+	Mm
		1246991 MY18A_MOUSE (36-569): 8.33e-10: 64.4: 13.13		UBP15_MOUSE (1-981): 0: 858: 97.66
+	Hs
		850145 SPDLY_HUMAN (1-605): 2.11e-78: 261: 100.00		UBP11_HUMAN (9-946): 0: 661: 43.58
+	Hs
		724724 MYH9_HUMAN (4-596): 3.84e-17: 87.9: 13.74		UBP11_HUMAN (9-946): 0: 661: 43.58
+	Hs
		725119 MYH10_HUMAN (4-596): 7.47e-17: 87.1: 11.71		UBP11_HUMAN (9-946): 0: 661: 43.58
+	Hs
		850129 MY18A_HUMAN (36-569): 9.74e-11: 67.1: 14.03		UBP11_HUMAN (9-946): 0: 661: 43.58
+	Hs
		1174154 SPDLY_HUMAN (1-605): 2.11e-78: 261: 100.00		UBP45_HUMAN (288-932): 2.23e-75: 266: 17.97
+	Hs
		551869 DESP_HUMAN (15-507): 8.07e-47: 179: 14.37		UBP22_HUMAN (772-933): 1.82e-57: 208: 32.20
+	Hs
		724889 MYH9_HUMAN (4-596): 3.84e-17: 87.9: 13.74		UBP45_HUMAN (288-932): 2.23e-75: 266: 17.97
+	Hs
		725186 MYH10_HUMAN (4-596): 7.47e-17: 87.1: 11.71		UBP45_HUMAN (288-932): 2.23e-75: 266: 17.97
+	Hs
		271039 MYH9_HUMAN (4-596): 3.84e-17: 87.9: 13.74		UBP2_HUMAN (647-935): 1.13e-62: 226: 25.09