HitPredict

Interactor 1: SIR1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: SIRT1

Interactor 2: WDR76 (Q9H967)
WD repeat-containing protein 76
Gene: WDR76

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	31353912, 33961781
Identification Methods	affinity chromatography technology, biochemical, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000792 - heterochromatin GO:0005634 - nucleus GO:0006974 - DNA damage response GO:0019899 - enzyme binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 747 Hs			1 626
+	Hs
		1246141 SIR1_HUMAN (1-747): 0: 1052: 100.00		COP1_HUMAN (154-619): 7.6e-71: 245: 14.96
+	Hs
		1281302 SIR1_HUMAN (1-747): 0: 1052: 100.00		FBXW7_HUMAN (180-616): 3.15e-66: 231: 11.79
+	Hs
		997850 SIR1_HUMAN (1-747): 0: 1052: 100.00		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55
+	Hs
		1236403 SIR6_HUMAN (230-546): 7.12e-92: 292: 21.77		DDB2_HUMAN (201-625): 1.38e-70: 236: 21.51
+	Hs
		1344499 SIR7_HUMAN (179-541): 2.86e-87: 282: 19.15		NLE1_HUMAN (181-575): 1.3e-63: 219: 12.70
+	Hs
		997813 SIR6_HUMAN (230-546): 7.12e-92: 292: 21.77		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55
+	Hs
		997925 SIR7_HUMAN (179-541): 2.86e-87: 282: 19.15		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55