Protein: SYNJ1
Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)

Gene: SYNJ1
Organism: Homo sapiens
Interactions: 87
UniProt ID: O43426

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004438 - phosphatidylinositol-3-phosphate phosphatase activity
GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

215961

SNX9
Sorting nexin-9

4

5

Small-scale

0.702

High

215914

GRB2
Growth factor receptor-bound protein 2

4

20

High-throughput

0.697

High

215941

AP2M1
AP-2 complex subunit mu

4

1

Small-scale

0.696

High

215946

SH3G2
Endophilin-A1

3

20

Small-scale

0.674

High

215908

AMPH
Amphiphysin

3

6

Small-scale

0.671

High

215925

ITSN1
Intersectin-1

2

12

Small-scale

0.628

High

215938

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

Small-scale

0.624

High

215886

SRBS2
Sorbin and SH3 domain-containing protein 2

2

20

Small-scale

0.614

High

215915

AP2B1
AP-2 complex subunit beta

2

12

High-throughput

0.611

High

215928

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

4

Small-scale

0.602

High

215896

CLCA
Clathrin light chain A

2

4

Small-scale

0.595

High

215898

TAU
Microtubule-associated protein tau

2

4

Small-scale

0.552

High

215905

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.541

High

215927

SH319
SH3 domain-containing protein 19

1

20

High-throughput

0.541

High

215943

SH3Y1
SH3 domain-containing YSC84-like protein 1

1

20

High-throughput

0.541

High

215947

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

High-throughput

0.541

High

215955

NGAP
Ras GTPase-activating protein nGAP

1

2

High-throughput

0.541

High

215885

VINEX
Vinexin

1

20

High-throughput

0.536

High

215913

1433G
14-3-3 protein gamma

1

15

High-throughput

0.536

High

215918

1433F
14-3-3 protein eta

1

15

High-throughput

0.536

High

215919

AP1B1
AP-1 complex subunit beta-1

1

11

High-throughput

0.536

High

104888

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

215940

FXRD1
FAD-dependent oxidoreductase domain-containing protein 1

1

0

High-throughput

0.518

High

47932

RBM47
RNA-binding protein 47

1

0

High-throughput

0.513

High

215951

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

215920

MYO1E
Unconventional myosin-Ie

1

5

Small-scale

0.506

High

215889

AP2A1
AP-2 complex subunit alpha-1

1

12

Small-scale

0.501

High

215903

NCK1
SH2/SH3 adapter protein NCK1

1

20

Small-scale

0.501

High

215917

CLH1
Clathrin heavy chain 1

1

4

Small-scale

0.501

High

215945

SH3G1
Endophilin-A2

1

20

Small-scale

0.501

High

215948

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

9

Small-scale

0.501

High

215957

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

12

Small-scale

0.501

High

215960

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

9

Small-scale

0.501

High

215888

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

Small-scale

0.480

High

156574

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

1

High-throughput

0.479

High

189325

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

210512

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

2

High-throughput

0.479

High

215883

STX6
Syntaxin-6

1

4

High-throughput

0.479

High

215887

AP2A2
AP-2 complex subunit alpha-2

1

12

High-throughput

0.479

High

215890

RASK
GTPase KRas

1

15

High-throughput

0.479

High

215893

LCK
Tyrosine-protein kinase Lck

1

13

High-throughput

0.479

High

215894

PROF1
Profilin-1

1

3

High-throughput

0.479

High

215895

VIME
Vimentin

1

5

High-throughput

0.479

High

215897

CLCB
Clathrin light chain B

1

4

High-throughput

0.479

High

215899

FGFR1
Fibroblast growth factor receptor 1

1

11

High-throughput

0.479

High

215900

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

215901

CADH1
Cadherin-1

1

1

High-throughput

0.479

High

215902

EZRI
Ezrin

1

2

High-throughput

0.479

High

215904

VINC
Vinculin

1

1

High-throughput

0.479

High

215906

PERI
Peripherin

1

5

High-throughput

0.479

High

215909

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.479

High

215916

ACTC
Actin, alpha cardiac muscle 1

1

6

High-throughput

0.479

High

215922

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

215923

HDAC1
Histone deacetylase 1

1

3

High-throughput

0.479

High

215926

CCDC6
Coiled-coil domain-containing protein 6

1

5

High-throughput

0.479

High

215933

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

215934

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.479

High

215935

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

215936

BICD2
Protein bicaudal D homolog 2

1

8

High-throughput

0.479

High

215937

SMAP2
Stromal membrane-associated protein 2

1

1

High-throughput

0.479

High

215942

BICD1
Protein bicaudal D homolog 1

1

8

High-throughput

0.479

High

215944

SNX27
Sorting nexin-27

1

3

High-throughput

0.479

High

215950

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

215952

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.479

High

215953

ANFY1
Rabankyrin-5

1

1

High-throughput

0.479

High

215954

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

215958

MYO6
Unconventional myosin-VI

1

2

High-throughput

0.479

High

215962

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

2

High-throughput

0.479

High

215892

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.458

High

215921

REST
RE1-silencing transcription factor

1

0

High-throughput

0.458

High

215949

UNK
RING finger protein unkempt homolog

1

0

High-throughput

0.458

High

215911

AP2S1
AP-2 complex subunit sigma

1

4

High-throughput

0.445

High

215912

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

10

High-throughput

0.445

High

215924

RNPS1
RNA-binding protein with serine-rich domain 1

1

1

High-throughput

0.445

High

215931

PKHA7
Pleckstrin homology domain-containing family A member 7

1

4

High-throughput

0.445

High

215882

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.437

High

215884

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.437

High

215930

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.437

High

215939

PF21A
PHD finger protein 21A

1

1

High-throughput

0.437

High

215959

ALK
ALK tyrosine kinase receptor

1

9

High-throughput

0.437

High

215891

PRIO
Major prion protein

1

0

Small-scale

0.426

High

215932

ALKB2
DNA oxidative demethylase ALKBH2

2

0

High-throughput

0.328

High

214484

HXA2
Homeobox protein Hox-A2

1

0

High-throughput

0.279

Low

215907

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.279

Low

215910

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.279

Low

215929

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

215956

RCOR1
REST corepressor 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025