HitPredict

Interactor 1: SEH1 (Q96EE3)
Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein)
Gene: SEH1L

Interactor 2: NUP85 (Q9BW27)
Nuclear pore complex protein Nup85 (85 kDa nucleoporin) (FROUNT) (Nucleoporin Nup75) (Nucleoporin Nup85) (Pericentrin-1)
Gene: NUP85

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.918

Property	Details
Experiments	24927568, 26496610, 15146057, 26391640, 24315095
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, molecular sieving
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Nucleopor_Nup85~WD40
Common GO terms	GO:0000776 - kinetochore GO:0005635 - nuclear envelope GO:0005643 - nuclear pore GO:0005829 - cytosol GO:0006913 - nucleocytoplasmic transport and 1 others more... GO:0031080 - nuclear pore outer ring
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 360 Hs			1 656
+	Hs
		903486 WDR5_HUMAN (253-360): 5.88e-19: 88.4: 18.52		NUP85_HUMAN (1-656): 0: 834: 100.00
+	Hs
		878241 SEC13_HUMAN (216-346): 5.58e-17: 82.6: 18.80		NUP85_HUMAN (1-656): 0: 834: 100.00
+	Sc
		805096 SEC13_YEAST (7-319): 1.17e-73: 232: 29.84		NUP85_YEAST (100-636): 6.9e-138: 422: 15.16
+	Sp
		1013471 SEH1_SCHPO (110-339): 1.59e-17: 84.3: 16.10		NUP85_SCHPO (98-606): 9.3e-144: 435: 18.02
+	Sc
		805086 SEH1_YEAST (185-338): 3.3e-10: 62.7: 16.05		NUP85_YEAST (100-636): 6.9e-138: 422: 15.16