HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.637

Property	Details
Experiments	16189514, 36931259
Identification Methods	two hybrid, affinity chromatography technology, pull down, two hybrid pooling approach, cross-linking study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 970 Hs			1 248
+	Hs
		128986 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		128988 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		128970 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		128971 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		128985 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		128996 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	At
		1280891 CIPKC_ARATH (2-450): 1.29e-157: 475: 24.35		14337_ARATH (2-247): 4.35e-147: 413: 58.07
+	At
		788672 CIPKC_ARATH (2-450): 1.29e-157: 475: 24.35		14333_ARATH (3-247): 2.63e-144: 405: 58.30
+	At
		965360 CIPKC_ARATH (2-450): 1.29e-157: 475: 24.35		14332_ARATH (3-248): 2.23e-144: 405: 58.47
+	Hs
		909524 ROCK1_HUMAN (5-620): 1.38e-134: 439: 19.42		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Mm
		910234 MARK2_MOUSE (2-639): 7.37e-139: 436: 20.96		1433E_MOUSE (2-246): 4.41e-146: 410: 60.41
+	Mm
		983809 MARK2_MOUSE (2-639): 7.37e-139: 436: 20.96		1433B_MOUSE (1-239): 3.73e-99: 290: 68.62
+	Mm
		905332 MARK2_MOUSE (2-639): 7.37e-139: 436: 20.96		1433G_MOUSE (1-242): 1.86e-98: 289: 65.16
+	Mm
		935483 MARK2_MOUSE (2-639): 7.37e-139: 436: 20.96		1433F_MOUSE (2-242): 1.72e-96: 284: 64.20
+	Hs
		684360 PLK2_HUMAN (15-264): 1.56e-59: 218: 41.60		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		683915 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		910097 PLK2_HUMAN (15-264): 1.56e-59: 218: 41.60		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		861687 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		861686 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		861710 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20