HitPredict

Interactor 1: RNF31 (Q96EP0)
E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)
Gene: RNF31

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.766

The method score is based on:

Property Details
Experiments 21455180, 23732909, 23986494, 26577923, 28249776, 30561431, 30913450, 33815386, 36720498, 23032186, 21811235, 19675569, 29650758, 33215740, 34755089, 35851409, 36192478, 23032187, 24469399
Identification Methods affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation, virotrap, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005829 - cytosol
GO:0031625 - ubiquitin protein ligase binding
GO:0042742 - defense response to bacterium
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:0050852 - T cell receptor signaling pathway
and 3 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 1072
Hs

1 419
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024