HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: ALMS1 (Q8TCU4)
Centrosome-associated protein ALMS1 (Alstrom syndrome protein 1)
Gene: ALMS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	24613305, 27872092
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000922 - spindle pole GO:0005813 - centrosome GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 970 Hs			1 4168
+	Dm
		854031 POLO_DROME (12-265): 4.68e-64: 228: 42.91		SPEN_DROME (28-1791): 3.43e-16: 89.2: 7.19
+	Hs
		311841 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		TACC2_HUMAN (65-2284): 4.29e-30: 134: 8.42
+	Hs
		160565 AURKA_HUMAN (9-273): 3.28e-53: 193: 37.74		MDC1_HUMAN (706-2214): 6.64e-23: 110: 8.85
+	Hs
		1232421 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		CMYA5_HUMAN (6-2293): 5.89e-25: 118: 8.74
+	Hs
		1056933 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MDC1_HUMAN (706-2214): 6.64e-23: 110: 8.85
+	Hs
		160879 AURKA_HUMAN (9-273): 3.28e-53: 193: 37.74		NCOR2_HUMAN (62-1792): 9.19e-12: 74.4: 9.21
+	Hs
		727304 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		NU214_HUMAN (1222-2232): 5.74e-12: 74.7: 10.73