HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.658

Property	Details
Experiments	26871637, 20516151, 25503564
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 970 Hs			1 605
+	Hs
		129064 PLK4_HUMAN (1-970): 0: 1040: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		861990 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		160864 AURKA_HUMAN (9-273): 3.28e-53: 193: 37.74		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Sc
		419809 SNF1_YEAST (6-382): 4.46e-134: 418: 29.88		NLE1_YEAST (223-580): 1.69e-77: 256: 18.81
+	Dm
		332693 PLK4_DROME (6-662): 7.98e-125: 399: 32.09		Q9VDE3_DROME (466-605): 2.66e-30: 126: 29.37
+	Hs
		1281434 PLK2_HUMAN (15-264): 1.56e-59: 218: 41.60		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	At
		189130 CIPK2_ARATH (1-455): 1.29e-137: 421: 24.30		GBLPA_ARATH (439-584): 1.06e-09: 62.4: 31.21
+	Hs
		861879 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		160697 AURKA_HUMAN (9-273): 3.28e-53: 193: 37.74		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		1281310 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71